None listed
Conditions
Brief summary
Optic disc drusen (ODD) are common benign calcified deposits in the front of the optic nerve, and some doctors treat them as a type of glaucoma, by lowering the eye pressure, because the progressive visual field defects are similar. This treatment has never been tested because ODD are generally slow-changing. With new electrical recordings we seek to test whether the optic nerve cells are stressed in ODD and whether glaucoma treatment increases or decreases this stress signal.
Interventions
Latanoprost 0.005% eye drops to lower intraocular pressure. These are self administered by participants at home before bedtime once daily in both eyes for a total of one month until retesting (range 25-35 days). Bottles will be collected at completion, but the main test of compliance and efficacy will be a change in intraocular pressure.
Sponsors
Jesse Gale
Study design
Allocation
Non-randomised trial
Intervention model
Single group
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
10 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Diagnosed and verifiable optic disc drusen Willing and able to give consent (parental assent for those under 18) Baseline intraocular pressure of 15 mmHg or higher in one eye
Exclusion criteria
Inability to attend testing schedule Allergy to prostaglandin eye drops Active eye disease requiring treatment, ocular surgery within 6 months Pregnancy (or possible pregnancy during month of treatment)
Outcome results
None listed