None listed
Conditions
Brief summary
Impetigo is a common childhood illness which is more prevalent in tropical regions. Australian guidelines recommend treatment with topical or oral antibiotics depending on severity. There is currently insufficient evidence to support the use of non-antibiotic topical treatments. Prescription of antibiotics is an important issue as antimicrobial resistance is currently a serious threat to global health. Consequently, it is imperative that non-antibiotic treatments for common conditions are explored. This pilot study will explore topical antibiotics versus topical antiseptics versus inert vehicle ointment on the treatment of patients with impetigo, providing data to determine the feasibility of a future larger study.
Interventions
1. Hydrogen peroxide ointment applied to skin lesions with cotton bud, three times a day for 5 days, by the participant or their guardian if the participant is a child. All lesions to be covered with standardised dressings provided, dressing changes will occur at every application. Adherence will be monitored by use of a treatment diary to be completed by the participant and returned to the treating doctor at the completion of the intervention.
2. Soft white paraffin ointment applied to skin l
1. Hydrogen peroxide ointment applied to skin lesions with cotton bud, three times a day for 5 days, by the participant or their guardian if the participant is a child. All lesions to be covered with standardised dressings provided, dressing changes will occur at every application. Adherence will be monitored by use of a treatment diary to be completed by the participant and returned to the treating doctor at the completion of the intervention. 2. Soft white paraffin ointment applied to skin lesions with cotton bud, three times a day for 5 days, by the participant or their guardian if the participant is a child. All lesions to be covered with standardised dressings provided, dressing changes will occur at every application. Adherence will be monitored by use of a treatment diary to be completed by the participant and returned to the treating doctor at the completion of the intervention.
Sponsors
James Cook University
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
2 Years to No maximum
Healthy volunteers
No
Inclusion criteria
• <4 skin lesions • Lesions able to be covered with dressings • No allergy to Mupirocin®, hydrogen peroxide or soft white paraffin ointments • No current use of antibiotics • No use of topical therapeutic agents on lesions within the last 48 hours • No Concomitant underlying skin disease (e.g. eczematous dermatitis) • Immuno-compotent • Patients with a primary language is English or for which certifed translation services for that language are available
Exclusion criteria
• Systemic infection (e.g. fever, nausea, vomiting) • Aboriginal or Torres Strait Islander ethnicity.
Outcome results
None listed