None listed
Conditions
Brief summary
Acute Kidney Injury (AKI) following cardiac surgery is a significant cause of morbidity and mortality, affecting up to 30% of patients. It is unclear if 20% albumin infusion is useful in reducing the incidence of AKI in these patients. We hypothesise that an infusion of 20% albumin will reduce the incidence of perioperative AKI after high-risk cardiac surgery, compared with standard care.
Interventions
Intravenous infusion of 20% albumin. The infusion will begin within 6 hours of surgery and will be administered for 15 hours at 20mL/hour. The infusion will be given in addition to standard care as per the clinician in charge.
Adherence to the study protocol will be monitored via clinical notes (e.g. ICU observation charts).
Sponsors
Monash Health
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Prevention
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
- Age >18 years of age - At least one of the following: i. eGFR <60mL/min/1.73m2; or ii. Have had a combined valve and coronary procedure; or iii. 2 valve procedures; or iv. Surgery involving the thoracic aorta.
Exclusion criteria
Patients meeting any of the following criteria will be excluded from the study: - eGFR <15mL/min/1.73m2 - Serum albumin <20g/L - Dialysis dependence - Kidney transplant - Undergoing off-pump coronary bypass surgery - Requring extra-corporeal life support or ventricular assist device immediately post-operative - Jehovah’s Witness
Outcome results
None listed