Skip to content

How nutrition supplements may improve exercise capacity in people with Chronic Obstructive Pulmonary Disease attending outpatient pulmonary rehabilitation program.

The effect of nutritional supplementation on exercise capacity in people with Chronic Obstructive Pulmonary Disease attending pulmonary rehabilitation. A non-randomised intervention pilot study.

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12619001354178
Enrollment
19
Registered
2019-10-03
Start date
2019-09-03
Completion date
Unknown
Last updated
2021-03-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The primary objective of this study is to determine if nutritional supplementation improves exercise capacity in patients with Chronic Obstructive Pulmonary Disease (COPD) attending pulmonary rehabilitation. Secondary aims of this study are to evaluate if nutritional supplementation results in greater improvements in hand grip strength, body weight, body mass index (BMI), nutritional status (MNA), health related quality of life and lower limb strength in people with COPD participating in pulmonary rehabilitation. Participants will attend an 8 week (16 session) pulmonary exercise rehabilitation program which consists of two 1.5 hour exercise sessions per week. Participants that consent to take the nutritional supplement will be assigned to the intervention group and will be asked to take a nutritional supplement daily for the period of their 8-week exercise rehabilitation program. Participants who decline to take the nutritional supplement will be invited to also take part in the study and will be assigned to the Control Group (non-randomised) and asked to complete baseline and follow up outcome measures only. Overseas studies have shown that nutritonal supplements improve exercise outcomes for patients with COPD attending pulmonary rehabilitation and we aim to see if this can be replicated in the Australian population.

Interventions

Participants in intervention group: Participants who agree to consume a nutritional supplement will be provided with the nutritional supplement Fortisip compact protein for the duration of their program. Fortisip compact protein is a ready-to-drink, high energy, high protein, vitamin and mineral rich oral nutritional supplement containing 300 kcal and 18 g protein per 125 ml bottle. Fortisip compact protein is a liquid formulation produced by Nutricia Advanced Medical Nutrition and is a commo

Participants in intervention group: Participants who agree to consume a nutritional supplement will be provided with the nutritional supplement Fortisip compact protein for the duration of their program. Fortisip compact protein is a ready-to-drink, high energy, high protein, vitamin and mineral rich oral nutritional supplement containing 300 kcal and 18 g protein per 125 ml bottle. Fortisip compact protein is a liquid formulation produced by Nutricia Advanced Medical Nutrition and is a common nutritional supplement recommended and provided in some NSW hospitals as well as outpatient and community health settings as a standard process for nutrition intervention. Participants of this study will be required to consume one 125ml Fortisip compact protein daily orally for the duration of the program (16 sessions/8weeks). Participants will be encouraged to consume the nutritional supplement at time of physical activity however compliance of this will not be monitored. To monitor adherence, participants will be provided with a compliance log sheet and they will be requested to sign off daily once they have consumed their nutritional supplement. Participants will be requested to bring their compliance log sheet in weekly at their scheduled exercise session. Participants in non- randomised control group: Intervention and control participants will need to attend twice weekly pulmonary rehabilitation group exercise sessions for eight weeks facilitated by the physiotherapists. Each exercise session runs for 1.5hours. Participant’s level of intensity whilst completing exercise session is monitored using the Borg Scale of Perceived Exertion. Intensity is moderate, set at Borg/ RPE of 3-4. The exercise session includes: a walking track, stationary cycling, treadmill, upper limb exercises with dumbbells and therabands, lower limb exercises mostly using the patient’s body weight (e.g: sit-to-stand, stepping, lunges). Participants also complete one half hour nutrition group education session facilitated by a dietitian. As this is a ‘rolling’ program the nutrition session occurs at different stages of the 8 week program for each participant. Participants will be attending outpatient pulmonary rehabilitation program running at Royal North Shore Community Health Centre, Mona Vale Community Health Centre, Brookvale Community Health Centre, Ryde Hospital or Hornsby Ku-ring-gai Hospital. All participants will have the following measurements taken: Baseline measurements: Completed by physiotherapist: • 6MWT • Body weight, BMI • 5STS • St George’s respiratory questionnaire Completed by dietitian • Hand grip strength • MNA Discharge measurements: Completed by physiotherapist: • 6MWT • 5STS • St George’s respiratory questionnaire Completed by dietitian • Body weight, BMI • Hand grip strength • MNA

Sponsors

Chronic Disease Community Rehabilitation Service, Northern Sydney Local Health District
Lead SponsorHospital

Study design

Allocation
Non-randomised trial
Primary purpose
Treatment

Eligibility

Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

• Clinical diagnosis of COPD (FEV1/FVC <0.70) • Completion of pulmonary rehabilitation initial assessment including two 6MWTs • Willingness to give written informed consent and willingness to comply with the study procedures.

Exclusion criteria

• BMI >30kg/m2 • Milk allergy

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026