None listed
Conditions
Brief summary
Patients with AF frequently reports dyspnea upon exertion and exercise intolerance. However, the factors that contribute to these symptoms are not clear. In this study, we will objectively quantify exercise capacity, with the aim of assessing the impact of preselected clinical features on peak oxygen uptake and ventilatory efficiency.
Interventions
In this observational study, we will evaluate the influence of pre-specified anthropometric variables (height, body mass index), resting echocardiographic measures (Left Ventricular (LV) systolic function, LV diastolic function, LV diameter, Right Ventricular systolic function and left atrial volume) and comorbidities (type II diabetes, hypertension, obstructive sleep apnea) on peak oxygen uptake, assessed during cardiopulmonary exercise testing, amongst a cohort of paroxysmal and persistent atr
In this observational study, we will evaluate the influence of pre-specified anthropometric variables (height, body mass index), resting echocardiographic measures (Left Ventricular (LV) systolic function, LV diastolic function, LV diameter, Right Ventricular systolic function and left atrial volume) and comorbidities (type II diabetes, hypertension, obstructive sleep apnea) on peak oxygen uptake, assessed during cardiopulmonary exercise testing, amongst a cohort of paroxysmal and persistent atrial fibrillation patients. Study participants will undergo a cardiopulmonary exercise test (CPET, 8-15 minutes), resting transthoracic echocardiogram, clinical review and will undertake a atrial fibrillation specific symptom questionnaire (AFSS, Atrial Fibrillation Symptom Severity Questionnaire). CPET will involves walking on a treadmill at a fixed speed (default 5.3 km/h, tailored to the individual), with gradient increasing 1% per minute. All measures will be obtained within a 2 week period. There is no ongoing follow-up as part of this study.
Sponsors
University of Adelaide
Eligibility
Sex/Gender
All
Age
30 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
Paroxysmal or Persistent Atrial Fibrillation Aged 30-80 years
Exclusion criteria
Reduced Left Ventricular Ejection Fraction <50% Moderate to Severe Valvular DIsease Malignancy Recent Cardiac Surgery (<12 months) Recent Myocardial Infarction (<12 months)
Outcome results
None listed