Daily probiotic supplementation and symptoms of allergic rhinitis

Conditions

None listed

Brief summary

The symptoms of Allergic rhinitis, such as nasal congestion and itching, are a burden for an estimated 3.2 million Australians and its prevalence is increasing. There is growing evidence to suggest that probiotic supplementation elicits beneficial health effects on the host through modulation of the immune system and thereby can improve symptoms associated with Allergic rhinitis. The aim of this research is to examine the effect of probiotic supplementation on symptoms and quality of life in individuals suffering from Allergic rhinitis.

Amanda J. Cox, Rebecca Ramsey, Robert S. Ware, Isolde Besseling-van der Vaart, Allan W. Cripps et al. (6 authors)

Journal of Integrative and Complementary Medicine2023-05-013 citations

10.1089/jicm.2022.0734

Interventions

Daily probiotic Supplementation for 8 weeks. The supplement is in the form of a powder (2g twice daily) to be mixed with water and consumed orally. The supplement composition is as follows: Maize starch, Maltodextrins, Bacterial strains (Bifidobacterium bifidum W23, Lactobacillus acidophilus W55, Lactobacillus casei W56, Lactobacillus salivarius W57 and Lactococcus lactis W58 - >1x10^9 cfu/g) Vitamin B2 and Biotin. Compliance will be encouraged with a daily checklist and monitored by supplemen

Daily probiotic Supplementation for 8 weeks. The supplement is in the form of a powder (2g twice daily) to be mixed with water and consumed orally. The supplement composition is as follows: Maize starch, Maltodextrins, Bacterial strains (Bifidobacterium bifidum W23, Lactobacillus acidophilus W55, Lactobacillus casei W56, Lactobacillus salivarius W57 and Lactococcus lactis W58 - >1x10^9 cfu/g) Vitamin B2 and Biotin. Compliance will be encouraged with a daily checklist and monitored by supplementation return at the end of the intervention period.

Study design

Allocation

Randomised controlled trial

Primary purpose

Treatment

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Healthy volunteers

No

Inclusion criteria

• Be Male or female; • Be aged between 18-65 years; • Have more than 2 years history of moderate to severe persistent allergic rhinitis; • Have moderate to severe allergic rhinitis as rated by the Allergic Rhinitis and its Impact on Asthma (ARIA) criteria • Have a positive radio-allergosorbent test (RAST) to Bermuda (couch) grass.

Exclusion criteria

• Have non-allergic rhinitis • Have a negative RAST to Bermuda grass • Report consumption of probiotics or prebiotics in the previous 12 weeks; • Report treatment with systemic corticosteroids in the previous 6 months; • Have a history of respiratory diseases such as nasal polyposis and COPD ; • Have a current respiratory viral infectious disease (common cold); • Report current pregnancy or attempting to become pregnant; • Report use of medications which effect salivary flow and components such as systemic corticosteroids, diuretics and antidepressants; • Allergic, sensitive or intolerant to (one of) the ingredients of the study product.

Outcome results