None listed
Conditions
Brief summary
The iCOMP collaboration aims to perform a systematic review and network meta-analysis, using individual participant data, of trials that have assessed different cord management strategies at preterm birth, e.g. delayed cord clamping, cord milking, etc. We are bringing together all completed, ongoing and planned trials on this topic to synthesise all the available data. This work will be crucial in identifying optimal cord management strategies for key subgroups of preterm infants.
Interventions
Cord management strategies to influence umbilical flow and placental transfusion, including, but not limited to:
• Short deferral of cord clamping (more than 15 to less than 45 seconds) without milking
• Medium deferral of cord clamping (more than or equal to 45 to less than 90 seconds) without milking
• Long deferral of cord clamping (more than or equal to 90 seconds) without milking
• Cord milking or stripping before immediate cord clamping
• Cord milking or stripping before deferred cord clam
Cord management strategies to influence umbilical flow and placental transfusion, including, but not limited to: • Short deferral of cord clamping (more than 15 to less than 45 seconds) without milking • Medium deferral of cord clamping (more than or equal to 45 to less than 90 seconds) without milking • Long deferral of cord clamping (more than or equal to 90 seconds) without milking • Cord milking or stripping before immediate cord clamping • Cord milking or stripping before deferred cord clamping • Cord milking or stripping after immediate cord clamping • Cord milking or stripping after deferred cord clamping • Physiological clamping (clamping after aeration of lungs) Duration of follow-up varies across included trials, but may be up to 2 years.
Sponsors
NHMRC Clinical Trials Centre, University of Sydney
Eligibility
Sex/Gender
All
Age
No minimum to 50 Years
Healthy volunteers
No
Inclusion criteria
Studies will be included if they are randomised trials. Studies must compare at least two of the interventions of interest. Participants will be women giving birth preterm (before 37 completed weeks’ gestation) and/or their babies. Women and babies will be included regardless of whether mode of delivery was vaginal or Caesarean, and whether the birth was singleton or multiple. Babies will be included regardless of whether or not they received immediate resuscitation at birth.
Exclusion criteria
quasi-random studies will be excluded
Outcome results
None listed