None listed
Conditions
Brief summary
Globally, by 2050, every one in two people will be myopic. It is in fact a vision-threatening public health issue. Interestingly, it has been found that there is seasonal variation in ocular growth with less growth during summer months. Additionally, ocular parameters such as eye length have also been reported to exhibit a diurnal rhythm. This observational study aims to investigate variations in ocular parameters over 24 hours and to evaluate their associations with the body clock and daily light exposure among healthy young adults.
Interventions
This is an observational study and no intervention will be given to participants.
A screening will be arranged for participants who expressed interest in order to determine their ocular health and eligibility for this study. The screening will take about 30 minutes. Participants who are not suitable will be excluded. Clinic visit appointments will be scheduled for participants who are eligible to participate.
On the testing day, participants will attend 7 visits (up to 30 minutes per visit) over
This is an observational study and no intervention will be given to participants. A screening will be arranged for participants who expressed interest in order to determine their ocular health and eligibility for this study. The screening will take about 30 minutes. Participants who are not suitable will be excluded. Clinic visit appointments will be scheduled for participants who are eligible to participate. On the testing day, participants will attend 7 visits (up to 30 minutes per visit) over 24 hours. During the night time (from 8pm to 8am on the following day), participants will be asked to remain in the clinic as a safety precaution. Participants will each have their own room and will be encouraged to sleep during the night.
Sponsors
Brien Holden Vision Institute Limited
Eligibility
Sex/Gender
All
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
• Adults with good general health, age range 18 to 35 years • Best-corrected visual acuity of 20/20 or better in each eye, with or without refractive error • Have ocular health findings considered to be ‘normal’ (E.g. no ocular diseases or history of eye surgery) • Willing to sign informed consent and comply with study schedule • Willing to stay in the clinic for overnight measurements
Exclusion criteria
• Current smokers • Pregnant women • Colour vision deficiency • Intraocular pressure > 21 mmHg • Anterior and posterior ocular anomalies • Unusual pupil findings, including relative afferent pupil defect (RAPD), anisocoria, mydriasis or miosis, etc. • Systemic diseases that may affect ocular health (e.g. hypertension, diabetes mellitus, etc.) • Use of or a need for any systemic medication or topical medications which may alter normal ocular findings / are known to affect a participant’s ocular health / physiology either in an adverse or beneficial manner • Use of or a need for any systemic medication or topical medications which may / are known to affect the pupil light response (e.g. psychiatric medications) • Use of myopia control medications or devices • Use of melatonin or any pharmacological sleep aids • Experienced jet lag within one month before participating in the study
Outcome results
None listed