None listed
Conditions
Brief summary
Percutaneous coronary intervention (PCI) in acute coronary syndrome (ACS) patients is associated with a higher incidence of peri-procedural myocardial infarction. An increased release of neutrophil-derived inflammatory products is known to contribute to this process. Colchicine is a well-established anti-inflammatory drug, however its role in attenuating post-PCI release of activated neutrophil-mediators is not well known. This pilot study aims to investigate whether peri-procedural colchicine would suppress local release of Neutrophil Extracellular Traps, and its components Human Neutrophil Elastase and Myeloperoxidases, in both ACS and stable angina pectoris patients.
Interventions
All colchicine administered was administered 6 to 24 hours prior to coronary angiography. This is due to uncertainty in waiting time for the angiogram depending on the angiogram list. Within this 6-24 hour window, the treatment group received TWO doses of colchicine. The first dose was a 1 mg oral tablet. After receiving this first dose, the second dose was a 0.5 mg oral tablet given 1 hour later. Hence all treatment group patients received 1.5mg of colchicine in total.
Colchicine was administ
All colchicine administered was administered 6 to 24 hours prior to coronary angiography. This is due to uncertainty in waiting time for the angiogram depending on the angiogram list. Within this 6-24 hour window, the treatment group received TWO doses of colchicine. The first dose was a 1 mg oral tablet. After receiving this first dose, the second dose was a 0.5 mg oral tablet given 1 hour later. Hence all treatment group patients received 1.5mg of colchicine in total. Colchicine was administered in alternating fashion, with every other patient receiving no colchicine. All patients underwent coronary angiogram.
Sponsors
Sanjay Patel
Study design
Allocation
Non-randomised trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Patients with clinical indication for coronary angiogram and percutaneous coronary intervention.
Exclusion criteria
- Patients with >50% Left main artery stenosis - Patients with cardiogenic shock - Patients with haemodynamic instability - Patients currently lactating - Patients with known colchicine hypersensitivity - Patients already taking colchicine before the procedure.
Outcome results
None listed