None listed
Conditions
Brief summary
The present study is designed to explore a link between cognitive decline post-surgery as a cause of vitamin C decline following the surgery. The aim of the study is to to determine whether surgery has an effect on vitamin C levels and cognition with the use of a neuropsychological test battery. It is hypothesised that elective hip surgery will result in significantly depleted plasma vitamin C concentrations which will contribute to compromised cognitive function on the cognitive assessments. Cognitive tests will involve both paper and pen and computer tests, while blood tests will be undertaken to measure plasma vitamin C and serum vitamin B12 levels and levels of inflammation. Testing will be conducted roughly 1-2 weeks prior to the scheduled surgery and subsequent testing sessions will be performed within 1 week, 4-6 weeks, 3 months and 6 months after surgery.
Interventions
Particiapnts will include adults aged between 65-85 yrs., who are undergoing elective hip surgery or age matched control participants on the waiting list or suffering from hip issues such as osteoarthritis. Consenting participants will have their surgery details (i.e. length and type of surgery, type of anaesthetic used, and any complications) distributed to the researcher. Participants will be required to primarily undergo a series of cognitive assessments and blood tests during each testing se
Particiapnts will include adults aged between 65-85 yrs., who are undergoing elective hip surgery or age matched control participants on the waiting list or suffering from hip issues such as osteoarthritis. Consenting participants will have their surgery details (i.e. length and type of surgery, type of anaesthetic used, and any complications) distributed to the researcher. Participants will be required to primarily undergo a series of cognitive assessments and blood tests during each testing session. Participants will be required to fast for each testing session and attend a total of 5 study sessions: • Visit 1: 1-2 weeks prior to surgery (Tests conducted at NIIM in Hawthorn) • Visit 2: within 1 week after surgery (Tests conducted at the hospital) • Visit 3: 4-6 weeks after surgery (Tests conducted at NIIM in Hawthorn) • Visit 4: 3 months after surgery (Tests conducted at NIIM in Hawthorn) • Visit 5: 6 months after surgery (Tests conducted at NIIM in Hawthorn) Each visit will take approximately 2.5-3 hours. Cognitive tests will involve both paper and pen and computer tests. The paper and pen tests will include the Symbol Digits Modalities Test (SDMT), and the Hopkins verbal learning test revised (HVLT-R). The computerised cognitive assessment will be the Swinburne University Computerised Cognitive Assessment Battery (SUCCAB). A blood test will be taken to measure plasma vitamin C and serum vitamin B12 levels and cytokine levels. Alongside the cognitve test and blood test, 5 Questionnaires which include a demographic and medical history questionnaire, a pain questionnaire, food frequency questionnaires, a sleep questionnaire, a mood questionnaire and wound healing questionnaire. A pulse wave velocity test (which tests for arterial stiffness) and blood pressure test will be conducted.
Sponsors
National Institute of Integrative Medicine (NIIM)
Eligibility
Sex/Gender
All
Age
65 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
-Adults 65-85 yrs. scheduled for elective hip replacement orthopaedic surgery or age matched control participants on the waiting list or suffering from hip issues such as osteoarthritis or pain/discomfort. - Exposed to spinal anaesthetic and heavy sedation during surgery -Good comprehension of written and spoken English -Able to give informed consent -Must not be taking antidepressants, antipsychotics, anxiolytics, illicit drugs or any cognitive enhancing drugs - Not taking any vitamin C or vitamin B12 supplementation post-operatively for the duration of the study
Exclusion criteria
-Colour blindness or any other severe visual impairment -Pregnant or lactating -Cognitive impairment (3MS score < 79) -History of neurological or psychiatric disorders
Outcome results
None listed