None listed
Conditions
Brief summary
Wisdom tooth extraction often causes significant local tissue injury in a highly innervated area. This results in significant pain and loss of function. Reduced ability to open the jaw often also accompanies pain and lasts for several days. Dental nerves can express TRPV1, TRPA1 and TRPM3 and are known in allergy work to cause pain when stimulated by inflammatory mediators. Two products, a spray and cream, have been developed that target these receptors via a topical approach. This study will assess pain and mobility after a reproducible "injury" following wisdom teeth surgery, compared to placebo.
Interventions
Topical application of 2.5g (half a teaspoon) of TRP modulating cream and 1mL of spray following wisdom tooth extraction to the jawline and external cheek at site of wisdom tooth extraction as required for up to five days.
Active ingredients are as follows:
a. Mentha Arvensis (Peppermint Oil)0.1%
b. Chamonilla Recutia (Matricaria) Flower oil 0.05%
c. Panax Ginseng Extract 5%
d. Aloe Vera powder 0.5%
e. Taurine 0.35%
f. Glycyrrhiza blabra (Liquorice extract)1%
g. Norhydroguiaretic acid 3%
h. Ep
Topical application of 2.5g (half a teaspoon) of TRP modulating cream and 1mL of spray following wisdom tooth extraction to the jawline and external cheek at site of wisdom tooth extraction as required for up to five days. Active ingredients are as follows: a. Mentha Arvensis (Peppermint Oil)0.1% b. Chamonilla Recutia (Matricaria) Flower oil 0.05% c. Panax Ginseng Extract 5% d. Aloe Vera powder 0.5% e. Taurine 0.35% f. Glycyrrhiza blabra (Liquorice extract)1% g. Norhydroguiaretic acid 3% h. Epigallocatechin3gallate (EGCG) (Green Tea)0.05% These are compounded with 25% glycerol.
Sponsors
Professor Peter Smith
Study design
Allocation
Randomised controlled trial
Primary purpose
Treatment
Eligibility
Sex/Gender
All
Age
14 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Patients undergoing bilateral wisdom tooth extraction, 14 years and over.
Exclusion criteria
Patients with an intolerance to the spray, allergic reaction to spray/placebo ingredients, intellectually disabled participants and persons that speak languages other than English.
Outcome results
None listed