None listed
Conditions
Brief summary
This study will consist of a prospective randomised control trial comparing standard perioperative care for primary total knee replacement with and without the addition of a perioperative dose of methylprednisolone. We aim to determine the best peri-operative pain control for patients undergoing this painful procedure whilst limiting the risks. This is hypothesised to allow early gains in range of movement, hospital discharge and reduction in post operative nausea and vomiting, postural hypotension, post operative analgesia requirements and an improvement in knee scores. Patients will be assessed daily during their inpatient stay and then at 2 and 6 weeks for pain control, satisfaction, signs of infection and range of movement. The study will be conducted over a three month time frame. This information will be used to enhance pain control for future patients whilst reducing risks. It is also expected to enhance the patient journey for those undergoing TKA at SJOG Murdoch.
Interventions
Prospective randomised control trial comparing standard perioperative care for primary total knee replacement with and without the addition of perioperative doses of methylprednisolone- 125mg at induction and 12hrs postoperatively administered intravenously. Doses will be given during hospital admission and adherence to the intervention will be monitored by drug chart review.
The addition of methylprednisolone 125mg IV at induction and 12hrs postop will be the treatment intervention.
Sponsors
Orthopaedics WA
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
>18yo Primary Osteoarthritis BMI <40
Exclusion criteria
Inflammatory arthritis Prior knee surgery Revision surgery Infection Diabetes - Type one and two
Outcome results
None listed