None listed
Conditions
Brief summary
The primary objectives will be to assess the effects of different sweetened beverages on cognition, mood and satiety. The sweeteners will induce different glycaemic responses in the participants. The study hypothesis is that a beverage which can induce a higher blood glucose concentration and then a higher glucose concentration in the brain, represented by the sucrose treatment, will result in better cognitive and mood results. Another hypothesis is that a more steady blood glucose concentration will result in greater feelings of satiety. The study will have a crossover design in which each participant will consume a sucrose, an isomaltulose and a sucralose sweetened drinks in randomized order. Participants will attend three sessions with at least one-week washout time. On each test day, participants will be given cognitive tests 60 minutes following beverage ingestion, including the Complex Figure test, the Word Recall test, the Trail Making test (Part B) and the Stroop Word Colour test. Mood questionnaires will be answered before and 60 minutes following beverage ingestion and satiety questionnaires will be answered before, 30, 60, and 90 minutes following beverage ingestion.
Interventions
This will be a double-blind crossover trial in which 55 healthy adults will drink three kinds of sweetened beverages; a drink containing 50g sucrose as the higher glycaemic response arm, a drink containing 50g isomaltulose and 0.035g sucralose as the lower glycaemic response arm, and a drink containing 0.12g sucralose as the negative control arm. The order in which participants receive the drinks will be randomised to each person. On the evening prior to the test day, participants will be asked
This will be a double-blind crossover trial in which 55 healthy adults will drink three kinds of sweetened beverages; a drink containing 50g sucrose as the higher glycaemic response arm, a drink containing 50g isomaltulose and 0.035g sucralose as the lower glycaemic response arm, and a drink containing 0.12g sucralose as the negative control arm. The order in which participants receive the drinks will be randomised to each person. On the evening prior to the test day, participants will be asked to fast from 9pm onwards with water only being permitted, resulting in an overnight fast of 10 hours. On the mornings of the test days, participants will be provided with a 500ml beverage and asked to drink it within 10 minutes. There will be at least one-week washout between test days. On the day prior to each test, an email will be sent to participants to remind them to fast from 9pm onwards.
Sponsors
University of Otago
Study design
Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
18 Years to 64 Years
Healthy volunteers
Yes
Inclusion criteria
Healthy adults
Exclusion criteria
Pregnancy, breastfeeding, a diagnosis of pre-diabetes or diabetes, high blood pressure, heart disease, cancer, high cholesterol levels, liver disease, kidney disease, intestinal disease and clinical depression, or intolerance to or allergy to sucralose or isomaltulose, colour blind
Outcome results
None listed