None listed
Conditions
Brief summary
patients with second degree facial burns will be treated, and will be divided into two groups. Cellular amnion will be applied on the face after wound wash in group A and Acellular amnion in group B. Both groups will be compared for wound healing time, hypersensitivity reaction, pain, infection and need for skin grafting. the results will be compared in both the groups.
Interventions
Amnion will be obtained after informed consent from enrolled healthy expecting mothers undergoing C-section, with no co-morbidities or infections, testing negative for HBV, HCV and HIV. Meconium-contaminated placenta would be discarded. Amnion will be separated from placenta by washing with large volumes of normal saline. Membranes would then be transferred to another container containing 70% glycerol and refrigerated at 4 degree Centigrade. For Group A, Amnion will be retrieved from the fridge, dipped in normal saline for 10 min to remove glycerol and single layer of amnion will be applied to the cleaned and dried facial burns by the primary investigator, ensuring no air bubbles between it and the bed. Topical antibiotic ointment (Polyfax Ointment - Glaxosmithkline) will be applied three times a day up-to 2 at least 2 weeks up-to 1 month. No secondary dressing will be applied. The amnion will remain there till the burn wound epithelization at least 2 weeks and up to 1 month.
Sponsors
Study design
Eligibility
Inclusion criteria
2nd degree facial burns
Exclusion criteria
Burn more at 48 hours at presentation Patients with full thickness facial burns