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comparison of cellular versus acellular amnion in superficial burns of the face.

Outcome Of Cellular Versus Acellular Amnion In Superficial Facial Burn: A Randomized Trial

Status
Not yet recruiting
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12619001050145
Enrollment
60
Registered
2019-07-25
Start date
2019-07-26
Completion date
Unknown
Last updated
2019-08-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

patients with second degree facial burns will be treated, and will be divided into two groups. Cellular amnion will be applied on the face after wound wash in group A and Acellular amnion in group B. Both groups will be compared for wound healing time, hypersensitivity reaction, pain, infection and need for skin grafting. the results will be compared in both the groups.

Interventions

Amnion will be obtained after informed consent from enrolled healthy expecting mothers undergoing C-section, with no co-morbidities or infections, testing negative for HBV, HCV and HIV. Meconium-contaminated placenta would be discarded. Amnion will be separated from placenta by washing with large volumes of normal saline. Membranes would then be transferred to another container containing 70% glycerol and refrigerated at 4 degree Centigrade. For Group A, Amnion will be retrieved from the fridge, dipped in normal saline for 10 min to remove glycerol and single layer of amnion will be applied to the cleaned and dried facial burns by the primary investigator, ensuring no air bubbles between it and the bed. Topical antibiotic ointment (Polyfax Ointment - Glaxosmithkline) will be applied three times a day up-to 2 at least 2 weeks up-to 1 month. No secondary dressing will be applied. The amnion will remain there till the burn wound epithelization at least 2 weeks and up to 1 month.

Sponsors

Farrukh Aslam Khalid
Lead SponsorIndividual

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Open (masking not used)

Eligibility

Sex/Gender
All
Age
20 Years to 50 Years
Healthy volunteers
No

Inclusion criteria

2nd degree facial burns

Exclusion criteria

Burn more at 48 hours at presentation Patients with full thickness facial burns

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026