None listed
Conditions
Brief summary
Elevated fasting plasma insulin and triglyceride levels are known to increase the risk for cardiovascular disease (CVD) and type 2 diabetes. Although the measure of fasting plasma triglyceride and insulin levels may represent a cumulative effect of the dietary habits and disease, it does not allow the understanding of the contribution of individual foods/meals to CVD risk. Therefore, the development of a postprandial measure that includes both triglycerides and insulin is warranted to understand the effect of food/meals on the development of chronic diseases. A standardised meal is used as a comparator for three isocaloric test meals of varying macronutrient composition.
Interventions
Eligible participants agreed to participate in this study will be asked to visit our clinical facilities at the University of Newcastle, Callaghan campus. They will be asked to provide a completed consent form, complete a brief medical questionnaire, a physical activity questionnaire, 24-hour food recall. The day before each appointment participants will be asked to refrain from physical activity and alcohol consumption for 24 hours, to consume a meal low in calories, the evening before the test
Eligible participants agreed to participate in this study will be asked to visit our clinical facilities at the University of Newcastle, Callaghan campus. They will be asked to provide a completed consent form, complete a brief medical questionnaire, a physical activity questionnaire, 24-hour food recall. The day before each appointment participants will be asked to refrain from physical activity and alcohol consumption for 24 hours, to consume a meal low in calories, the evening before the test day (low-calorie meal is based on instructions provided by the study investigators after the screening) and fast for 10 hours. Participants will have their anthropometric measurements (weight, height, body muscle mass, etc.) and blood pressure taken, followed by a donation of one venous blood sample in fasting state. Following blood collection, study investigators will serve a reference meal (Bread, wholemeal, 2 regular slices; butter (1 x 7g tub); Peanut butter, crunchy (1 x 11g tub); OAK chocolate 250 mL) by study investigators. Participants must stay at the study site for the entire duration (3.5 hours) of each session. They will then have a blood sample collected 3 hours after meal consumption. Participants will have to consume the meal within 20 minutes. Meal consumption was monitored through direct observation of the study investigator. This visit will be repeated with a washout period of 3 days between each appointment. GlucoTRIG value of the test meals will be evaluated a wash out period of 3 days between each appointment. Test meal -1 Uncle Toby’s Oats Quick Sachets Original- 2 sachets Raw almonds, with skin - 9 nut Skim Milk - 200mL Banana, fresh, Cavendish - 1 medium Test meal - 2 Greek Yogurt Plain Fat-Free - 170g Melon, watermelon - 300g Red Kidney Beans -170g Carrot, fresh, unpeeled - 200g Berri Juice Tomato- 300mL Test meal - 3 Ferrero Nutella Hazelnut Spread - 20g Wholemeal & Seeds - 2 regular slices Up&Go Energize Iced Coffee Flavour - 170g
Sponsors
Riddet Institute
Study design
Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Prevention
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
Inclusion criteria: • Healthy male or female aged between 18 and 40 years old at initial assessment • Body mass index (BMI ) between 18 and 30 Kg/m2.
Exclusion criteria
Exclusion criteria: Subjects will be excluded from the intervention if they: • Take any lipid-lowering drugs or supplements (e.g. statins, fish oil) or anti-hypertensive drugs; • Are dieting or have any eating disorders; • Have allergy or intolerance to any of the food products or ingredients used; • Have a history of congestive heart failure, stroke, myocardial infarction, coronary artery bypass graft, or atherosclerotic CVD; • Have a history of diabetes, hypertension, triglycerides higher than 3 mmol/L; total cholesterol higher than 5 mmol/L; • Have a history of the gastrointestinal disorder or liver disease; • Smoke; • Are pregnant or breastfeeding
Outcome results
None listed