Mean platelet volume in asymptomatic chorioamnionitis exposed term infants

Mean platelet volume (MPV) in chorioamnionitis-exposed asymptomatic neonates. A retrospective case control study

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12619000935134

Enrollment

130

Registered

2019-07-04

Start date

2019-07-10

Completion date

2019-09-10

Last updated

2019-07-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Maternal chorioamnionitis (CA) is serious problem causing significant neonatal morbidities and long term neurodevelopmental sequalae in exposed infants. Current guidelines still recommend admission, laboratory evaluation, and antibiotic administration to all chorioamnionitis exposed infants. The incidence of early onset sepsis is currently low with the routine intrapartum antibiotics administration to mothers at risk. New diagnostic tools are needed for early diagnosis of sepsis in apparently healthy infants exposed to chorioamnionitis. Mean platelet volume (MPV) measurement was evolving as a potential inflammatory marker in neonatal sepsis in different studies. We aim to study whether MPV in asymptomatic chorioamnionitis-exposed infants can be used as an adjuvant diagnostic tool of early onset sepsis in these infants.

Interventions

All asymptomatic full term chorioamnionitis (CA) exposed infants admitted to Neonatal intensive care unit (NICU) from May 2016 until may 2019 will be enrolled. Blood samples from CA exposed infants to examine for Full blood count indices and C-reactive protein (CRP) data will be collected. These data will be compared to the information retrieved from control group who are healthy infants delivered to healthy mothers with uneventful pregnancies. The aim is to examine the significance of mean platelet volume as a significant marker for early onset sepsis in CA exposed infants. Blood samples from CA exposed infants group are collected on admission (day 1) and again on day 3 after receiving 48 hours course of antibiotic treatment.

Eligibility

Sex/Gender

All

Age

0 to 6 Hours

Healthy volunteers

Yes

Inclusion criteria

1- Term infants 37 weeks gestation or more who are borne to chorioamnionitis mothers. 2- All infants were healthy asymptomatic at birth and after admission.

Exclusion criteria

1- Preterm infants <37 weeks gestation 2- Symptomatic term infants (Apnea, respiratory distress, cyanosis, poor feeding, temperature instability, hypoglycemia, or seizures) 3-Birth asphyxia 4-Infants with hematologic disorders or chromosomal anomalies.

Outcome results