None listed
Conditions
Brief summary
Recent studies have described the change in blood magnesium levels following its administration to children, pregnant women and patients who have had cardiac surgery. We wish to study the effects of IV magnesium supplementation in the general adult ICU population, specifically those who are receiving both ventilatory and blood pressure support. We also wish to study the effect of kidney function on IV magnesium supplementation in these patients. We aim to assess the blood and urine levels of magnesium immediately prior to and during magnesium replacement, administered as a 1-hour bolus followed by a 24-hour infusion, in 30 critically ill patients admitted to the Austin Hospital ICU. Blood and urine samples are already routinely collected in ICU patients for monitoring purposes; it is not anticipated that the additional tests would cause any harm. Retrospectively, we will also record basic demographic and admission details about the patients so that we can appropriately describe the study cohort. It is hoped that the information gathered from this study would fill a fundamental gap in our knowledge of IV magnesium supplementation in the critically unwell patient, helping clinicians to standardise their practice regarding the usage of magnesium.
Interventions
Administration of intravenous 10 mmol bolus of magnesium sulphate over 1 hour followed by a continues magnesium infusion of 1.5-3.0 mmol/hr to maintain serum magnesium levels between 1.5 - 2.0 mmol/L until intensive care unit discharge
Sponsors
Austin Hospital
Study design
Allocation
Non-randomised trial
Intervention model
Single group
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Admitted to the intensive care unit aged equal to or greater than 18 years existing intra-arterial catheter existing central venous catheter existing indwelling urinary catheter mechanically ventilated via an endotracehael tube receiving vasopressor supportive therapy treating clinician decides that intravenous magnesium replacement is necessary
Exclusion criteria
admission following cardiac surgery allergy to magnesium sulphate or one of its excipients pregnancy already receiving or had received a continuous intravenous magenesium infusion in the previous 24 hours currently receiving a muscle relaxant infusion at the time of screening has a serum creatinine concentration of greater than 200 micrommol/L at the time of screening is receiving renal replacement therapy
Outcome results
None listed