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Caffeine and anaerobic exercise performance: an exploration of caffeine’s effects on performance in young men and the influence of genotype on the variation in responses

The effect of CYP1A2 genotype on the ergogenic effects of caffeine during anaerobic exercise

Status
Completed
Phases
Early Phase 1
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12619000885190
Enrollment
22
Registered
2019-06-21
Start date
2019-08-01
Completion date
2019-11-25
Last updated
2020-03-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The aim of the study will be to investigate the effects of caffeine (3 mg/kg 60 min pre-exercise) on vertical jump performance, movement velocity in resistance exercise, muscular endurance, and power output. Additionally, the aim is to explore if the inter-individual variation in responses to caffeine ingestion influenced by variations in genotype. The study hypothesis is that individuals classified as AA genotype will experience greater improvements in exercise performance following caffeine ingestion than those with AC and CC genotypes.

Interventions

Caffeine supplementation. Dose: 3 mg per kg of body weight The duration of administration: only on one occasion. Mode of administration: oral tablet. Wash out period between the caffeine and placebo conditions is from 4 to 7 days. The CYP1A2 genotype will be assessed using a buccal swab sample collected before the caffeine and placebo conditions.

Sponsors

Victoria University
Lead SponsorUniversity

Study design

Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Caregiver, Outcomes Assessor)

Eligibility

Sex/Gender
Male
Age
18 Years to 40 Years
Healthy volunteers
Yes

Inclusion criteria

The sample size will consist of resistance-trained men. Resistance-trained men will be defined as having a minimum of 6 months of resistance training experience with a minimum weekly training frequency of two times on most weeks.

Exclusion criteria

The exclusion criteria will be: (1) current smoker; (2) prior or current use of anabolic steroids; and (3) existence of health limitations.

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 19, 2026