None listed
Conditions
Brief summary
Previous studies have shown that short term (3-7days) overfeeding and overfeeding with high fat (with predominantly saturated fat) can lead to increased fasting glucose, impaired glucose tolerance as well as impaired insulin sensitivity in humans. But it is not known if the impaired glucose tolerance induced by short term high fat overfeeding is linked to impaired microvascular blood flow in skeletal muscle and adipose tissue. This is what we aim to test in this study. We hypothesise that 7 days of overfeeding will impair skeletal muscle and adipose microvascular blood flow and contribute to glucose tolerance.
Interventions
High calorie, high fat feeding for 7 days in healthy people. This will include 50% higher energy intake than usual with energy 30% from CHO, 50% from fat and 20% from Protein. The participants will be required to consume their usual diet plus the snacks provided by the investigatory team (including biscuits, chocolate bars, yoghurt and use of coconut oil). The dietary intervention will be overseen by the team dietitian. The participants will be required to record the snacks consumed each day on
High calorie, high fat feeding for 7 days in healthy people. This will include 50% higher energy intake than usual with energy 30% from CHO, 50% from fat and 20% from Protein. The participants will be required to consume their usual diet plus the snacks provided by the investigatory team (including biscuits, chocolate bars, yoghurt and use of coconut oil). The dietary intervention will be overseen by the team dietitian. The participants will be required to record the snacks consumed each day on a checklist provided. The participants will also need to provide one day food diary before the pre and post fasting tests.
Sponsors
Deakin University
Study design
Allocation
Non-randomised trial
Intervention model
Single group
Primary purpose
Prevention
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
• Age 18-45 years • BMI 18-24.9 Kg/m2. • Normotensive (seated brachial blood pressure <140/90 mmHg). • Have given signed informed consent to participate in the study. • Have no known food allergies. • Have been weight stable for past 3 months.
Exclusion criteria
Update • Not meeting the inclusion criteria outlined above • Smoking status – regular smoker in the last 10 years and/or >10 years of smoking history • History of severe liver disease, any vascular or cardiovascular disease or type 2 diabetes • Pregnancy/lactation • Family history of type 2 diabetes (i.e. a parent with type 2 diabetes). • Person on a high fat diet (e.g. keto diet). • Person on a high saturated fat diet (>18% energy from saturated fat).
Outcome results
None listed