None listed
Conditions
Brief summary
This study will investigate the effects of cheese consumption on metabolic and gut health in healthy human subjects. Individuals participating in this study will be required to follow their usual diet (habitual diet) with minor adjustments regarding the consumption of cheese and dairy fermented products. Investigating the effects of cheese in the habitual diet under free living conditions will generate clinically relevant results and knowledge. The primary aim of this project is to characterise the response of the saliva, urine and stool microbiome and metabolome to habitual diets that differ in their type of production (quality)
Interventions
This pilot study will use a two arm randomized controlled trial design. The twenty-four (n=24) participants will be randomly split into two groups of twelve (n=12). Treatment for group 1: commercial cheddar cheese Treatment for group 2: Artisanal cheddar cheese All of the following study protocols are common to both groups: For the duration of the study period, participants will be required to not consume any fermented dairy products - excluding the cheese provided to them. To monitor adherence to the intervention, participants will be asked to record the food diary three times a week (one weekend and two week days). Also the researcher will call them every week to determine whether or not they follow up the intervention. Week 1(days 1-7): For the duration of one week, at the start, all participants will be asked to consume their normal diet with the omission of fermented dairy products (wash out period) . Week 2 (days 8-14): participants will be supplied with 350g of cheese (one week's supply; one-year-old commercially produced cheddar cheese or one-year-old artisanal cheddar cheese , dependent on their randomized allocation). Participants will be instructed to consume 50 g cheese/day (25 g twice daily) for the duration of one week. Week 3 (days 15-21): Participants will be supplied with another week's supply of cheese (350g) ( one-year-old commercially produced cheddar cheese or one-year-old artisanal cheddar cheese , dependent on their randomized allocation) and will be advised to consume 50g of cheese/day as during week 2. Week 4 (days 22-28: Participants will be asked to return to their normal diet (post-intervention period).
Sponsors
Study design
Eligibility
Inclusion criteria
Healthy weight (body mass index 18.5 - 25kg/m2) males and females adults (aged between 18 and 50) who are deemed eligible to participate as indicated by not meeting one or more of the exclusion criterion.
Exclusion criteria
Participants will be excluded from participating within the project for the following reasons: Individuals with presence of chronic diseases related to the metabolism of energy and nutrients (i.e. hyperthyroidism, diagnosed diabetes), pathologic eating disorders and lactose intolerance and allergy to dairy products. Additional exclusion criteria include: individuals with the presence of gastrointestinal disorders and diseases (i.e. inflammatory bowel disease, irritable bowel syndrome, coeliac disease, gastroenteritis), pregnant, post-menopausal, taking contraindicated mediation (i.e. psychotropic drugs, antibiotics or appetite suppressants), the use of any dietary supplement that might interfere with the results of the study, weight unstable in the past 3 months, or irregular bowel patterns