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Does Moffett’s solution cause greater post-operative throat pain compared to Co-phenylcaine in sinonasal surgery?

A comparison of post-operative throat pain in patients prepared with Moffett's solution versus Co-phenylcaine in sinonasal surgery.

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12619000772145
Acronym
MoCo
Enrollment
30
Registered
2019-05-24
Start date
2018-05-01
Completion date
2019-04-01
Last updated
2019-07-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The purpose of the study is to determine whether there is increased post-operative throat pain associated with Moffett's solution nasal preparation when compared with Co-phenylcaine. We hypothesize that there will be an increased in post-operative throat pain in the Moffett's solution group.

Interventions

The intervention-arm (twenty patients) were decongested with Moffett’s solution (The solution consisted of a mixture of 2mL of 10% cocaine solution (200mg), 1mL of 1:1000 adrenaline, 2mL of sodium bicarbonate and 5mL of 0.9% sodium chloride solution, 10mL in total with 5mL applied to each side). The Moffett's solution will be administered immediately prior to surgery by atomiser nasal spray. The control-arm (ten patients) with Co-phenylcaine, which will also be administered immediately prior to

The intervention-arm (twenty patients) were decongested with Moffett’s solution (The solution consisted of a mixture of 2mL of 10% cocaine solution (200mg), 1mL of 1:1000 adrenaline, 2mL of sodium bicarbonate and 5mL of 0.9% sodium chloride solution, 10mL in total with 5mL applied to each side). The Moffett's solution will be administered immediately prior to surgery by atomiser nasal spray. The control-arm (ten patients) with Co-phenylcaine, which will also be administered immediately prior to surgery by nasal nozzles spray. There solutions are both routinely used by Ear Nose and Throat surgeons in Australia.

Sponsors

Department of otolaryngology, Westmead Hospital
Lead SponsorHospital

Study design

Allocation
Non-randomised trial
Primary purpose
Treatment

Eligibility

Sex/Gender
All
Age
15 Years to 75 Years
Healthy volunteers
No

Inclusion criteria

Patients undergoing routine sinonasal surgery (septoplasty, turbinate surgery, functional endoscopic sinus surgery) requiring nasal preparation.

Exclusion criteria

Patients with a history of previous sinonasal surgery were excluded from the study.

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 21, 2026