None listed
Conditions
Brief summary
Acute exposure to fatty acid in the oral cavity leads to a satiety response (both hormonal and behavioural) in rodent models. However, this has never been shown in human studies. In addition, there is a large variation in taste sensitivity to fatty acid among humans. Therefore, it is possible that variation in fatty acid taste sensitivity might influence the efficacy of a fatty acid-mediated satiety response. The primary aim of this study was to assess whether oral exposure to a high concentration fatty acid solution would affect satiety in healthy Australian adults. The secondary aim was to assess whether fatty acid taste sensitivity would modify the aforementioned effect.
Interventions
Treatment is a 30 second oral rinse of a 20 mM oleic acid solution in skim milk. Treatment is provided on two separate days and placebo on another two separate days, in a random order. The washout period between treatments and/or placebos is at least 24 hours.
Sponsors
Professor Russell Keast
Study design
Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
Aged between 18-50 years; able to attend four laboratory testing sessions in the CASS lab at Deakin University; willing to fast overnight prior to each testing session; willing to consume milk and wheat products
Exclusion criteria
Allergic or intolerant to wheat or dairy; smoker; non-fluent in English; pregnant or lactating; on a diet that restricted energy consumption; had an illness or condition that precluded them from fasting overnight (e.g. diabetes mellitus)
Outcome results
None listed