Does brain connectivity in healthy adults influence the induction of spatial neglect by non-invasive brain stimulation?

Transcranial Magnetic Stimulation (TMS) Prior to the continuous theta burst stimulation (cTBS) intervention, the participant’s resting motor threshold (RMT) will be found by using a TMS stimulator (Magstim Super Rapid stimulator (Magstim Company, Dyfed, UK)) with RMT settings, placed perpendicular to the scalp over the right motor cortex at C4 on the 10/10 EEG cap. Electrodes will be placed over the participant’s left first dorsal interosseous muscle, so that motor evoked potentials can be monitored to devise the individual’s resting motor threshold. 70% of this threshold will then used as the intensity for the cTBS intervention. The same TMS stimulator will then be used to generate a continuous theta burst stimulation (cTBS). The continuous train (bi-phasic wave form) will be delivered using an air-cooled, figure-of-eight coil, which will be held perpendicular to the scalp, by the trained, primary examiner over the right parietal cortex, located at P4 according to the 10/10 EEG system. The cTBS will last for 40 seconds, 600 pulses will be applied in three bursts at 50Hz, repeated at 5 H. The intervention will be delivered once to each participant, face to face at the University of South Australia Clinical Trials Facility.