Brain Oxygenation changes during Heart Surgery

Changes in cerebral mitochondrial oxygenation during paediatric and adult cardiac surgery

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12619000605190

Enrollment

Registered

2019-04-23

Start date

2020-12-21

Completion date

2027-01-01

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The aim of this pilot study is to evaluate the relationship between intraoperative blood pressure and brain metabolism during heart surgery using an advanced non-invasive optical imaging technique . We hypothesise that drops in perfusion pressure (below the limit of cerebral autoregulation) which are frequently encountered in heart surgery, not only impair cerebral haemodynamics, but also affect brain metabolism. This research will extend this extensive programme of research for the first time to the cardiac surgical population. This pilot study will inform the feasibility of future studies comparing [oxCCO] with clinical outcomes following cardiac surgery.

Interventions

Patients undergoing heart surgery will have their brain cytochrome oxygenation status monitoring using the miniCYRIL near infrared system, together with standard clinical monitoring. This data will not be available to clinicians. Monitoring will commence ten minutes prior to surgical incision, and conclude on application of surgical dressings at the end of the operation.

Eligibility

Sex/Gender

All

Healthy volunteers

Inclusion criteria

adults and children undergoing heart surgery using cardiopulmonary bypass

Exclusion criteria

cerebral and cranial malformations involving frontal bone and cortex.

Outcome results