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Virtual reality for the treatment of cancer pain

The effects of virtual reality on pain intensity in people with cancer-related pain

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12619000568112
Enrollment
13
Registered
2019-04-11
Start date
2020-04-08
Completion date
2021-05-07
Last updated
2022-05-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This study will evaluate the effects of virtual reality on pain intensity in people with cancer-related pain Who is it for? You may be eligible to join this study if you are aged 18 and above, have a current or previous cancer diagnosis and are experiencing pain for at least a month Study details Participants in this study will receive both immersive and non-immersive virtual reality (VR) experiences but in a random sequence. Participants will attend once only where they undergo two 15-minute VR sessions with a one-hour washout period between sessions. The immersive session will comprise the use of immersive VR exploring a scene using an Oculus headset attached to a laptop. The non-immersive session will comprise viewing the same scene but directly watching the laptop screen. After each session, participants will be asked to answer questionnaires regarding pain intensity. A subset of participants will also undergo linear and non-linear electroencephalogram (EEG) analyses using a wireless EEG during the VR sessions to analyse regions of the brain that may be involved with pain. It is hoped that this research will contribute to the management of cancer-related pain using commercially available, non-pharmacological treatment applications that may improve health outcomes giving patients more control over their symptoms.

Interventions

1) A postdoctoral fellow with expertise in chronic pain research with deliver both virtual reality intervention and control protocols at Greenwich Hospital (Northern Sydney Local Health District). 2) To account for circadian influences on wakefulness, all study interventions will take place between 10.00am and 1.00pm. We will use a randomised crossover design. One hour will be required to collect baseline information, administer questionnaires and familiarise the participant with the VR set-up

1) A postdoctoral fellow with expertise in chronic pain research with deliver both virtual reality intervention and control protocols at Greenwich Hospital (Northern Sydney Local Health District). 2) To account for circadian influences on wakefulness, all study interventions will take place between 10.00am and 1.00pm. We will use a randomised crossover design. One hour will be required to collect baseline information, administer questionnaires and familiarise the participant with the VR set-up. 3) The participant will then undergo two interventions in randomised order. Each intervention will be 15 minutes duration with a 60-minute washout period between interventions. 4) Concerning the immersive intervention, participants will use Oculus Rift ® headsets to view and interact in an immersive virtual reality (VR) application. Using an easy-to-use hand-held touch controller, participants are able to move around a summer meadow environment (Nature Trek VR®) using simple hand movements that govern direction and speed. 6) During the set up period immediately prior to the start of the intervention, participants will be shown how to control their movement and speed within the VR environment. During the intervention, researchers will supervise both immersive VR and non-immersive computer display experiences in order to ensure participants are using the handheld devices correctly and to help if they get into difficulty using the hand-held devices 7) In a subset of participants, during each virtual reality session, a 32-channel wireless EEG recording will be administered to allow analysis of cortical regions that may be involved in cancer-related pain. Linear and non-linear EEG analyses will be performed to determine relationships between brainwave changes, cancer-related pain and influence of virtual reality.

Sponsors

Greenwich Hospital
Lead SponsorHospital

Study design

Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Treatment
Masking
Open (masking not used)

Eligibility

Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

1) Pain intensity equal or over 4/10 on numerical pain rating scale on enrolment for at least one month 2) Ambulatory from both home or research- based hospital 3) Life expectancy - 6 months and over 4) current or previous cancer diagnosis

Exclusion criteria

1) psychiatric comorbidities (not including anxiety and depression) 2) substance abuse 3) significant non-cancer pain 4) reduced ability to understand experimental tasks (e.g., lack of English language, dementia)

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026