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Investigation of association of central sensitization with postoperative outcomes in patients with total knee replacements

Investigation of association of central sensitization with postoperative outcomes in patients with total knee replacements

Status
Not yet recruiting
Phases
Unknown
Study type
Observational
Source
ANZCTR
Registry ID
ACTRN12619000459123
Enrollment
200
Registered
2019-03-20
Start date
2019-04-01
Completion date
Unknown
Last updated
2019-07-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Aims: To determine whether an individual’s response to pain, as measured by preoperative questionnaires examining pain hypervigilance and central sensitization, can accurately predict poor postoperative total knee replacement outcomes. Participants: All patients at Austin Health who are undergoing elective Total Knee Replacement Surgery Methods: - Patients who are undergoing an elective TKR at Austin Health will undertake voluntary questionnaires at preoperative physiotherapy clinic, and at postoperative review clinic at 3 weeks, 6 weeks and 12 months. - Patients at preoperative physiotherapy clinic and postoperative review clinics are currently routinely asked to do the Knee Society Score and Oxford Knee Score Questionnaires to monitor functional outcomes - Our proposed study would utilise this data, in addition to a preoperative, one-time questionnaire of the Pain Vigilance and Awareness Questionnaire (PVAQ) and Central Sensitisation Inventory (CSI) which are both validated questionnaires. - Our proposed study would also add a pre and postoperative additional functional score, the Forgotten Joint Score (FJS), another validated questionnaire. Expected Outcomes: We expect to see a pain hypervigilance (as measured by the PVAQ), and central sensitization (as measured by the CSI) to correlate with inferior postoperative outcomes.

Interventions

Aims: To determine whether an individual’s response to pain, as measured by preoperative questionnaires examining pain hypervigilance and central sensitization, can accurately predict poor postoperative total knee replacement outcomes. Patients will complete surveys at their routine pre-operative clinic appointment 1-2 months prior to surgery, and routine post-operative appointments at the 3 week, 6 week and 12 month mark post-operatively. Pre-operatively, they will complete the PVAQ (pain hyp

Aims: To determine whether an individual’s response to pain, as measured by preoperative questionnaires examining pain hypervigilance and central sensitization, can accurately predict poor postoperative total knee replacement outcomes. Patients will complete surveys at their routine pre-operative clinic appointment 1-2 months prior to surgery, and routine post-operative appointments at the 3 week, 6 week and 12 month mark post-operatively. Pre-operatively, they will complete the PVAQ (pain hypervigilance and awareness questionnaire), CSI (central sensitisation inventory), KOOS (knee osteoarthritis outcome score), OKS (oxford knee score) and FJS (forgotten joint score). Post-operatively they will complete the CSI (central sensitisation inventory), KOOS (knee osteoarthritis outcome score), OKS (oxford knee score) and FJS (forgotten joint score). Patients will complete surveys up to 12 months post-operatively (at 3 weeks, 6 weeks and 12 months).

Sponsors

Dr Michael Wang
Lead SponsorIndividual

Eligibility

Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

All adults (18+) undergoing elective Total Knee Replacement (TKR) for osteoarthritis of the knee.

Exclusion criteria

Individuals who wish to be excluded from the study or cannot participate due to issues with understanding, either due to language barriers or otherwise, such as intellectual disability. These individuals will be excluded from the study as this study relies upon data gathered through validated questionnaires that are self-administered after informed consent is obtained, with numerous questionnaires (CSI, FJS-12) not having validated versions available in numerous other languages. The internal validity of the study is difficult to maintain if individuals who are unable to understand the questionnaires presented are included in our patient cohort.

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026