The effect of MitoQ supplementation on cycling performance in trained individuals

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This study will be a randomised, double blind, crossover design, placebo-controlled trial. The intervention will involve the consumption of MitoQ. Testing will take place at the University of Auckland Grafton Campus. 25 healthy, trained male cyclists aged 35-50 years will be recruited to take part in the study. Participants will be asked to visit the University of Auckland Grafton Campus on 5 occasions over a period of 15 weeks to perform exercise on a stationary cycle ergometer. During visit 1, participants will have the study and PIS explained to them by the researcher and informed consent to participate in the trial will be obtained from those who meet the inclusion/exclusion criteria. Participants will be asked to complete a questionnaire that will obtain a history of exercise and health to determine their eligibility to participate in the study. Participants will undergo a maximal aerobic capacity test (VO2max) on a cycle ergometer. During visit 2 and 3 the participant will undergo a familiarisation to the exercise performance test. The exercise performance test will require the participants to cycle for 45 minutes at a fixed intensity of 70% of their peak work output (from VO2max test). Immediately after this initial loading period, participants will perform a 200 kJ workload time trial, during which they will complete 200 kJ of work on the bike, as fast as possible and at an intensity that they can determine themselves. This is equivalent to cycling 8km and is expected to take another 10-15 minutes. Participants will be randomly assigned to one of two groups, which will determine the order in which they receive MitoQ and the placebo. Participants will receive a tablet containing either MitoQ (20mg mitoquinol), or a placebo (tapioca powder, precipitated silica and microcrystalline cellulose 101) daily for 4 weeks before visit 4 and 5. Written instructions for consumption will be provided. Participants will be asked to complete a 3 day food diary prior to visits 4 and 5. Participants will be provided with a standard evening and breakfast meal for consumption on the evening and morning before visits 4 and 5. These meals will provide 25-30% of their daily caloric intake (60% of the calories as carbohydrates, 20% as protein and 20% as lipids). A cannula will be inserted into the participant’s antecubital fossa by a researcher who is trained in phlebotomy. Participants will then complete the exercise performance test and blood samples will be taken before exercise, after completion of the 45 minute loading period, and after exercise. There will be a 6 week washout period after visit 4. Participants will then cross over into the other treatment group before completing visit 5.

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