None listed
Conditions
Brief summary
The purpose of this study is to improve our understanding of coronary microvascular disease (small vessel disease in the blood vessels supplying the heart), and to evaluate whether microvascular disease correlates with poor outcomes. We aim to measure blood flow in the large and small vessels that supply the heart in a range of participants, as well as assess the function of the cells that line the blood vessels. We hope to enhance our knowledge in this area and develop new strategies to treat future patients with this under-recognized condition.
Interventions
Patients referred to the cardiac catheter laboratory are invited to participate in the study. Invasive physiology testing including fractional flow reserve and index of micro-circulatory resistance will be measured in all participants. Coronary pressure wires will be inserted into the coronary arteries via a guiding catheter, and measurements including pressure and mean saline transit time will be measured under both resting and hyperaemic conditions.
Every 5th presenting patient will also hav
Patients referred to the cardiac catheter laboratory are invited to participate in the study. Invasive physiology testing including fractional flow reserve and index of micro-circulatory resistance will be measured in all participants. Coronary pressure wires will be inserted into the coronary arteries via a guiding catheter, and measurements including pressure and mean saline transit time will be measured under both resting and hyperaemic conditions. Every 5th presenting patient will also have endothelial function and wall shear stress assessed. Patients will be followed up to 5 years, and be assessed for recurrent chest pain, revascularization, myocardial infarction, and death.
Sponsors
Royal Prince Alfred Hospital (Sydney Local Health District)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Patients referred to the cardiac catheter laboratory for coronary angiography or percutaneous coronary intervention
Exclusion criteria
Pregnancy, cardiogenic shock, contraindication to adenosine, severe asthma, heavily calcified or tortuous vessels leading to inability to advance pressure wire
Outcome results
None listed