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Reducing non-steroidal anti-inflammatory drug use in people with knee osteoarthritis

Reducing non-steroidal anti-inflammatory drug use in people with knee osteoarthritis: an assessment of feasibility and acceptability of a repeated measures study for risk minimisation

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12619000363189
Enrollment
3
Registered
2019-03-07
Start date
2019-09-11
Completion date
Unknown
Last updated
2019-12-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This study aims to determine the feasibility and acceptability of a 12-week online and individually-tailored physiotherapy intervention, involving exercise and coaching program in people with knee osteoarthritis who regularly take non-steroidal anti-inflammatory drugs. The intervention will be focused on reducing medication use, increase physical activity and pain management. The study will involve participants with knee osteoarthritis who regularly take non-steroidal anti-inflammatory drugs to be monitored for 6 weeks as they take their medication and seek care, as they normally would do (usual care). After 6 weeks, participants will start a 12-week online physiotherapy intervention, which will include 6 physiotherapy consultations involving strength training exercise, coaching to reduce medication use and improve physical activity, and pain coping skills training using an online platform (pain trainer).

Interventions

The intervention will involve participants receiving 6 individualised physiotherapy consultations and exercise via a web-application (Physitrack) over 12 week, following 6 weeks of usual care (total duration of study will be 18 weeks). An experienced and registered physiotherapist will be delivering one-on-one sessions for each participant. As the intervention will be delivered using a video-conferencing web-application, the sessions will be conducted at the participants’ homes. The first sessio

The intervention will involve participants receiving 6 individualised physiotherapy consultations and exercise via a web-application (Physitrack) over 12 week, following 6 weeks of usual care (total duration of study will be 18 weeks). An experienced and registered physiotherapist will be delivering one-on-one sessions for each participant. As the intervention will be delivered using a video-conferencing web-application, the sessions will be conducted at the participants’ homes. The first session (week 7) will be the longest and be approximately 60 minutes. The subsequent five sessions (week 8, 10, 12, 14, and 16) will be shorter and be approximately 30-40 minutes. The physiotherapy intervention will involve 1) an individually-tailored progressive-resistance exercise program; 2) health coaching to a) reduce medication and b) increase physical activity; and 3) online pain coping skills training (via Pain Trainer). During the intervention, the physiotherapist will also deliver education about osteoarthritis and non-steroidal anti-inflammatory drugs, and guideline-recommended. The home-based exercise program will be designed and administered according to the participants’ goals, abilities and preferences, using resistance bands. As per the ACSM guidelines for physical activity, participants will perform two to three sets of 6-10 repetitions of each exercise. This will be tailored to each participant. Exercise intensity will be set at equal to or more than 5 (hard) on the Modified Borg Rating of Perceived Exertion Scale. Participants will also receive health coaching via motivational interviewing to guide them towards reducing their reliance on NSAIDs and improving their physical activity levels to managing their condition. More specifically, participants will undergo motivational interviewing with their physiotherapist to address their goals and barriers, as well as assist participants in creating strategies to meet these goals and overcome their barriers. The therapist providing the intervention will be trained to be proficient in the health coaching process. Health coaching will be integrated in the six telephysiotherapy sessions, and should last approximately 20 minutes per session. All participants will also have access to an online pain coping skills training program, the Pain Trainer. This includes eight 40-minute modules focusing on different skills of pain coping. These modules will be introduced at the initial session but will be left to the patient to complete in their own time before the end of the study. The skills they learn will also be practiced in the scheduled sessions. Adherence to exercise will be monitored using a log book. We will also be asking participants to record any adverse events related to the exercise intervention, as well as any medication they are taking.

Sponsors

University of Sydney
Lead SponsorUniversity

Study design

Allocation
Non-randomised trial
Intervention model
Single group
Primary purpose
Treatment

Eligibility

Sex/Gender
All
Age
45 Years to No maximum
Healthy volunteers
No

Inclusion criteria

- Aged 45 years or older - Activity-related joint pain - Morning stiffness lasting <30 minutes - Report regular use of non-steroidal anti-inflammatory drugs of any class (the participants must have used them on average of 5 or more days in the previous 4 weeks before the commencement of the trial) - Have access to the Internet

Exclusion criteria

- Chronic systemic inflammatory conditions - Neurological condition affecting a participant’s ability to ambulate - Unstable cardiovascular condition - Regular use of strong opioids (e.g. morphine) - Participants must not be involved in any active therapy for their knee osteoarthritis such as a structured exercise program, designed by a physiotherapist but they can be involved in their own leisurely physical activity

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026