None listed
Conditions
Brief summary
To better understand why wild poliovirus persists in Gadap, and other such areas in Pakistan, it is important to know the proportion and age of children that lack mucosal immunity despite repeated polio vaccination campaigns. These are the children who do not necessarily become paralyzed when infected with poliovirus (PV) but who harbour the PV and further transmit it to others; resulting in continued low level PV circulation that has been observed in Gadap and other areas. It is known that mucosal immunity rapidly wanes however it is less well understood to what extend this immunity wanes in populations repeatedly vaccinated with OPV. Currently, IPV is added to the routine immunization program in Pakistan and therefore it is possible that there is a growing cohort of children whose humoral immunity is present but mucosal is absent. We intend to quantify this proportion and determine whether there are possible programmatic strategies to target these children.
Interventions
Children in intervention arm will be 9-10 or 14-15 years old - these children are not included in periodic polio vaccination campaigns which target children under 5 years of age
Children will receive one dose (two drops) of bivalent oral poliovirus vaccine (bOPV, Each dose [two-drops ~0.1 ml] contains not less than 10^6.0 CCID50 of Type 1 and 10^5.8 CCID50 of Type 3) as part of this study
Sponsors
World Health Organization
Study design
Allocation
Non-randomised trial
Primary purpose
Prevention
Eligibility
Sex/Gender
All
Age
1 Years to 15 Years
Healthy volunteers
Yes
Inclusion criteria
children living in study catchment area (Gadap Union Council 04, Karachi, Pakistan) aged 1-2 years or 4-5 years or 9-10 years or 14-15 years
Exclusion criteria
Suspected immunodeficiecny
Outcome results
None listed