Using routine pulse oximetry to estimate severity of lung problems in very premature infants.

Pulmonary ventilation-perfusion status in very preterm infants - non-invasive assessment utilising shift and shunt of the oxygen dissociation curve

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12619000314123

Enrollment

Registered

2019-02-28

Start date

2019-03-01

Completion date

Unknown

Last updated

2019-07-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The project aims to investigate the longitudinal trajectory of ventilation-perfusion mismatch measured using the Lockwood method in preterm infants less than 32 weeks of age at the end of first week, first month and 36 weeks postmenstrual age. This will be novel non-invasive data which may help to identify those infants at risk of developing bronchopulmonary dysplasia.

Interventions

Oxygen requirement of preterm infants and corresponding oxgyen saturation (SpO2) to estimate the ventilaton-perfusion (V:Q) ratio. This will be assessed at 3 time-points, at 1 week of age, 28 days and then at 36 weeks corrected gestational age. In brief, the assessment will involve where possible measurement of preductal SpO2 over a 30 minute to 1- hour period.

Eligibility

Sex/Gender

All

Age

0 to 72 Hours

Healthy volunteers

Inclusion criteria

Preterm infants <32 (or up to 31+6) weeks completed gestation

Exclusion criteria

1) Infants with severe congenital malformation 2) Lack of parental consent

Outcome results