None listed
Conditions
Brief summary
We aim to utilise a novel method for non-invasively estimating the ventilation-perfusion mismatch, a measure of the severity of lung disease of preterm babies with respiratory distress syndrome. The Lockwood algorithm uses routinely measure oxygen saturation levels paired with the amount of oxygen needed in order to calculate how much the oxygen dissociation curve has been "shifted" to provide a measure of the right-left shunt. This study aims to use measures of oxygen levels before and after surfactant treatment and the corresponding ventilation-perfusion levels in order to gauge response of the infant's lungs to surfactant treatment. The hypothesis is that the Lockwood measure will provide robust measure of ventilation-perfusion status in preterm infants with respiratory distress,
Interventions
Concentration of inspired oxygen (FiO2).
The amount of inspired oxygen (FiO2) that preterm infant needs to maintain oxygen within target range oxygen saturation (SpO2) of 91-95%, before and after surfactant administration. Before surfactant administration, this will be noted from observation of clinically needed interventions by nurses or doctors caring for the infant. The aim will be to record a minimum of 3 FiO2/SpO2 pairs. If these pairs are not available from clinically indicated change, th
Concentration of inspired oxygen (FiO2). The amount of inspired oxygen (FiO2) that preterm infant needs to maintain oxygen within target range oxygen saturation (SpO2) of 91-95%, before and after surfactant administration. Before surfactant administration, this will be noted from observation of clinically needed interventions by nurses or doctors caring for the infant. The aim will be to record a minimum of 3 FiO2/SpO2 pairs. If these pairs are not available from clinically indicated change, then FiO2 will be varied in small increments/decrements (of 1-2%) while ensuring is still within target range, i.e. intended SpO2 levels will always be within clinically indicated range, then returning this to the original FiO2 level. The aim will be to have at least 3 pairs of FiO2/SpO2 pairs overall. This observation will be repeated in the epoch post surfactant administration via minimally invasive surfactant therapy (MIST).
Sponsors
Monash Newborn
Eligibility
Sex/Gender
All
Age
No minimum to 3 Days
Healthy volunteers
No
Inclusion criteria
Preterm infants receiving minimally invasive surfactant therapy (MIST) while treated with non-invasive respiratory support Infants (born <36+6 weeks gestation) Diagnosis of Respiratory Distress Syndrome (RDS)
Exclusion criteria
Infant intubated for surfactant therapy Major congenital anomalies Infants who are very ill and unstable
Outcome results
None listed