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Comparing the impact of school-based and community-based deworming for controlling intestinal worm infections in school-aged children in Vietnam

School versus community-based albendazole deworming for control of soil transmitted helminths in school-age children in Vietnam – a cluster randomised controlled trial

Status
Not yet recruiting
Phases
Phase 4
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12619000309189
Acronym
CoDe-STH (COmmunity DEworming against STH)
Enrollment
7680
Registered
2019-02-28
Start date
2019-11-01
Completion date
2019-11-30
Last updated
2019-07-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This research project aims to determine if school-aged children are less likely to be reinfected with intestinal worms after deworming medication is delivered all community members, compared to when it is delivered only to school-aged children. Intestinal worms (referred to as soil-transmitted helminths or STH) infect nearly 1.5 billion individuals worldwide and can cause chronic health problems, especially in children. To treat intestinal worms in endemic countries, large-scale distribution of deworming medication occurs once or twice a year, usually targeted to school-aged children and delivered at school. Re-infection with intestinal worms is common in areas without adequate sanitation and hygiene, because infections are spread through soil contaminated with human faeces. We hypothesize that by expanding the delivery of deworming medications to all members of the community, there will be less contamination of soil with worm eggs and larvae, and children will therefore be less likely to be reinfected. To test this hypothesis, we will conduct a research study in Dak Lak province in Vietnam. The study will take place in 64 primary schools. These schools will be randomly allocated to either the “intervention” or “control” arm. In the intervention arm, deworming medication will be delivered both to all children at the primary school, and to all community members (except children under 1 year of age and pregnant women in the first trimester), in 2-3 communities that send children to the primary school. In the control arm, deworming medication will be delivered only to children at the primary school, which is the usual practice in Vietnam. Deworming medications will be delivered every 6 months for one year. Intestinal worm infections in school-aged children will be measured prior to each round of deworming to compare the impact of the two deworming approaches.

Interventions

In the intervention arm of the study, the drug albendazole will be given as a single dose of 400mg, to all students attending each study primary school (grades 1-5). This will be done once every six months for one year (3 doses in total). The drugs will be delivered by study researchers, at the primary school, and tablets taken under direct observation. In addition, in the 2-3 hamlets that send the most children to the primary school, single-dose albendazole 400mg will be delivered to all commun

In the intervention arm of the study, the drug albendazole will be given as a single dose of 400mg, to all students attending each study primary school (grades 1-5). This will be done once every six months for one year (3 doses in total). The drugs will be delivered by study researchers, at the primary school, and tablets taken under direct observation. In addition, in the 2-3 hamlets that send the most children to the primary school, single-dose albendazole 400mg will be delivered to all community members living in those hamlets. Children under 2 years of age will receive half a dose (200mg) as per World Health Organization (WHO) guidelines. Children under 1 year of age and pregnant women in the first trimester will be excluded from treatment as per WHO guidelines. The drugs will be delivered by the research team by going house-to-house in participating hamlets. All tablets will be taken under direct observation.

Sponsors

University of New South Wales
Lead SponsorUniversity

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Open (masking not used)

Eligibility

Sex/Gender
All
Age
5 Years to 12 Years
Healthy volunteers
Yes

Inclusion criteria

Children attending study primary schools, in grades 1-4

Exclusion criteria

Children attending study primary schools in grade 5

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 20, 2026