None listed
Conditions
Brief summary
Stroke affects millions of people worldwide. Endovascular treatment is an effective treatment for stroke patients with a blockage in a large brain artery. By collecting information about the brain scan changes from acute stroke patients, MOSES study aims to improve the way doctors use brain imaging in the future to guide endovascular treatment for stroke, leading to improved patient outcomes . Research questions: - Is there a certain volume of ischemic core (dead brain) (for example >100ml) beyond which benefits from thrombectomy are negated. -As age increases, does pre-treatment volume of dead brain for which a favorable outcome can be achieved decline? - Is the benefit of thrombectomy the same for distal (small) blocked arteries comparable to large blocked arteries? - How can we more accurately predict the outcome from thrombectomy in patients who will have long transfer times to a comprehensive stroke centre? - What is an ‘acceptable’ outcome, particularly in patients with a large volume of pre-treatment dead brain and/or premorbid disability. - For which groups of stroke patients does thrombectomy confer good ‘value for money’?
Interventions
The MOSES Registry will be a database of imaging and clinical stroke data of ischaemic stroke patients receiving thrombectomy. All clinical and imaging data is acquired as part of standard routine clinical practice. The imaging that will be uploaded, include:
- Pretreatment imaging (within 24 hours of stroke onset).
- Digital subtraction angiography (DSA) prior and post thrombectomy.
-Follow-up imaging (24-48 hours), in which may include Non-contrast computed tomography (NCCT)+/- computed tom
The MOSES Registry will be a database of imaging and clinical stroke data of ischaemic stroke patients receiving thrombectomy. All clinical and imaging data is acquired as part of standard routine clinical practice. The imaging that will be uploaded, include: - Pretreatment imaging (within 24 hours of stroke onset). - Digital subtraction angiography (DSA) prior and post thrombectomy. -Follow-up imaging (24-48 hours), in which may include Non-contrast computed tomography (NCCT)+/- computed tomography angiography (CTA) +/- computed tomography perfusion (CTP) and/or Magnetic resonance imaging (MRI). - Any additional imaging during acute hospital admission (e.g., if there is a clinical deterioration). Patients will be followed up at three-months, either face-to-face during out patient follow-up or via telephone. This includes Modified Rankin Scale and the EQ-5D-5L (quality of life).
Sponsors
Melbourne Health
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
-Patients who receive endovascular thrombectomy for ischemic stroke
Exclusion criteria
Patients who pass away before the patient/persons responsible information statement is given.
Outcome results
None listed