None listed
Conditions
Brief summary
This is a study to assess the effect of 12 months of blood or plasma donation on serum PFAS levels in a cohort of Metropolitan Fire Brigade (MFB) firefighters. The purpose of the study is to determine if regular blood donation (i.e. whole blood, or plasma donation) will be effective in reducing serum PFAS levels. Participants will be randomly allocated into one of the following three groups: a whole blood donation, a plasma donation or an observation only for a 12-month period. Group 1: Blood donation every 12 weeks Group 2: Plasma donation every 6 weeks Group 3: Observation alone The study will run for a total of 18 months (approximately 3 months screening and randomisation, 12 months intervention and 3 months follow up).
Interventions
Participants will be randomised to one of three groups.
Group one will donate blood every 12 weeks for 12 months, group two will donate plasma every 6 weeks for 12 months and group three will undergo no intervention.
Participants will have their donations checked by the study coordinator.
Sponsors
Macquarie University
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
1. Metropolitan Fire Brigade staff with 10 or more years of previous occupational exposure to PFAS. 2. PFOS levels >=5ng/mL 3. Eligible to donate blood (in accordance with the ARCBS guidelines). 4. Not donated blood in the past 3 months. 5. Signed and dated informed consent document indicating that the participant has been informed of all pertinent aspects of the trial prior to enrolment. 6. Willingness and ability to comply with scheduled visits, laboratory tests and other study procedures.
Exclusion criteria
1. Medical contraindication to blood donation. 2. Other severe acute or chronic medical or psychiatric condition, or laboratory abnormality that may increase the risk associated with study participation or study drug administration or may interfere with the interpretation of study results, and in the judgment of the investigator would make the participant inappropriate for entry into this study. 3. Previous ineligibility to donate blood. 4. Planned travel or extended leave (e.g. >6 weeks) that would prevent access to blood donation facilities.
Outcome results
None listed