None listed
Conditions
Brief summary
Disturbances of sleep occur frequently in the critically ill. Much less is known as to whether sleep disturbance is acute and resolves as patients recover, or is an issue that persists after hospital discharge and continues to adversely affect patients. Studies using patient subjective assessment suggest that sleep disturbances persist. However, only 28 patients in total (3 studies) have used objective measures (e.g. polysomnography) in ICU survivors to measure sleep, and in none of these three studies were measurements taken in ICU or hospital. This study will provide novel data as it will be the first comprehensive and objective longitudinal assessment of sleep disturbances in patients admitted to ICU. This inception cohort study will determine feasibility of objectively and subjectively measuring sleep, provide estimates of the proportion of long-stay ICU patients who have a new sleep disorder and evaluate whether sleep changes over time during critical illness and recovery.
Interventions
The following procedures will be carried out by a registered sleep scientist from Royal Melbourne Hospital over three defined study days.
The three study days are as follows:
- one on the RMH ICU (one night after 5 days of ICU admission)
- one on RMH ward (within 3 days of admission to ward)
- one at patient's home 90 days post-hospital discharge.
All objective measures of sleep will be carried out over one night, with the exception of the actigraphy, which will be worn by the participant fo
The following procedures will be carried out by a registered sleep scientist from Royal Melbourne Hospital over three defined study days. The three study days are as follows: - one on the RMH ICU (one night after 5 days of ICU admission) - one on RMH ward (within 3 days of admission to ward) - one at patient's home 90 days post-hospital discharge. All objective measures of sleep will be carried out over one night, with the exception of the actigraphy, which will be worn by the participant for up to 7 days prior to third study day. Actigraphy provides an objective measure of sleep-wake cycles via a non-invasive method attached to the upper limb. This will be used on all three study days. Portable Polysomnography is used for diagnostic purposes as a measure of assessing sleep disorders at home via electrodes being applied to the patient to assess different sleep parameters. This will be used on the final study day (at participant's home). Electroencephalogram with Electromyogram and Electrooculogram will be used to assess the electrical activity of the brain, muscle, and the eyes during the sleep-wake cycle. This involves non-invasive placing of electrodes on the scalp and jaw. This will be carried out on the first and second study day. Subjective assessment will also be carried out by two separate questionnaires - Epworth Sleepiness Scale, which is a subjective measurement of daytime sleepiness, and the Richards-Campbell Sleep Questionnaire, which evaluates sleep depth, efficiency, and quality. The questionnaires will be carried out on each study day either face-to-face or over the phone depending on participant availability.
Sponsors
Royal Melbourne Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Critically-ill patients admitted to ICU Aged >18 years Treated in RMH ICU for >/= 5 calendar days total Expected to remain in ICU for at least one more night
Exclusion criteria
Patients with a previously diagnosed sleeping disorder Patients with normal residence >50km from RMH Patients unlikely to survive 3 months from the first study day in ICU Patients unlikely to be discharged home within 3 months of the first study day in ICU Patients receiving thiopentone to achieve 'EEG burst suppression' Patients currently being treated for status epilepticus Patients whose ICU admission was a planned admission post-elective surgery Pregnancy Patients who are unable to provide informed consent via self or MTDM Patients who lack decision making capacity and are unable to identify a MTDM
Outcome results
None listed