None listed
Conditions
Brief summary
Infants born preterm are at risk of adverse long-term neurodevelopmental outcomes, including cognitive, behavioural and motor deficits (including cerebra palsy). These adverse outcomes can significantly impair social and educational functioning and quality of life. We have established a cohort of infants born very preterm (<31 weeks gestation) with early neonatal brain imaging and concurrent clinical assessment of motor, neurological and neurobehavioural function (PREMO - Prediction of Preterm Motor Outcomes, ACTRN12613000280707; PREBO - Prediction of Preterm Brain Outcomes, ACTRN12615000591550). This study now aims to examine whether early MRI scans or clinical assessments can predict a child’s motor, cognitive, language, educational achievement and mental health outcomes at 6 years corrected age. If this is found to be the case, then in future, families will be provided with information on their child’s likely development much earlier. This will enable families to receive support and their children to be offered earlier treatments to help them with their movement, learning or behavioural development.
Interventions
The PREBO-6 study is a prospective follow-up study of a cohort of children born very preterm (<31 weeks gestation) with early neonatal brain imaging and concurrent clinical assessment of motor, neurological and neurobehavioural function (PREMO - Prediction of Preterm Motor Outcomes, ACTRN12613000280707; PREBO - Prediction of Preterm Brain Outcomes, ACTRN12615000591550). We will now perform longer-term follow-up to capture longitudinal data on motor function, cognition, language, educational achi
The PREBO-6 study is a prospective follow-up study of a cohort of children born very preterm (<31 weeks gestation) with early neonatal brain imaging and concurrent clinical assessment of motor, neurological and neurobehavioural function (PREMO - Prediction of Preterm Motor Outcomes, ACTRN12613000280707; PREBO - Prediction of Preterm Brain Outcomes, ACTRN12615000591550). We will now perform longer-term follow-up to capture longitudinal data on motor function, cognition, language, educational achievement, mental health and brain structure at 6 years corrected age. This will be a one-off assessment conducted over 2 days.
Sponsors
Dr Joanne George
Eligibility
Sex/Gender
All
Age
6 Years to 6 Years
Healthy volunteers
Yes
Inclusion criteria
Children are eligible for this study if they participated in the PPREMO or PREBO prospective study, and turn 6 years corrected age within the study period. Preterm participants: Children who were born at <31 weeks gestation Term-born participants: Children who were born between 38 and 41 weeks gestation following an uncomplicated pregnancy and delivery, had a birth weight above the 10th percentile, and were not admitted to neonatal intensive or special care units following their birth.
Exclusion criteria
1) Children diagnosed with any congenital or chromosomal abnormality that could adversely affect their neurodevelopmental outcome. 2) Non-English speaking families.
Outcome results
None listed