None listed
Conditions
Brief summary
Due to the current increase of bacterial resistance to antibiotics, our main objective is to assess whether the use of an antibiotic for the extraction of a retained mandibular third molar is really useful in reducing the risk of infection. In this study we will compare the infection, inflammation and pain in patients who have taken different antibiotic treatments and patients who have not taken any antibiotics. Our study hypothesis is that in healthy patients won't be necessary any antibiotic treatment for the extraction of a third molar without infection, so that we can reduce the consumption of antibiotics and the presence of bacterial resistances.
Interventions
Use of preoperative and postoperative antibiotic prophylaxis for the extraction of retained mandibular third molar. Patients will be divided in three groups.
-Group 1: it will be formed by thirty patients. They will be given one tablet of amoxicillin 750 mg each 8 hours. Patients will start the treatment two days before the extraction and will continue it until five days later.
-Group 2: it will be formed by thirty patients. This group will take a placebo two days before the extraction and will
Use of preoperative and postoperative antibiotic prophylaxis for the extraction of retained mandibular third molar. Patients will be divided in three groups. -Group 1: it will be formed by thirty patients. They will be given one tablet of amoxicillin 750 mg each 8 hours. Patients will start the treatment two days before the extraction and will continue it until five days later. -Group 2: it will be formed by thirty patients. This group will take a placebo two days before the extraction and will take the same amoxicillin 750 mg treatment each 8 hours 5 days later. -Group 3: it will be formed by thirty patients too. They will be administrated placebo each 8 hours. Patients will start the treatment two days before the extraction and will continue it until five days later. The extractions will be made by students of the Master of Oral Surgery and Implantology in the University of Granada. For monitoring the intervention, the principal investigator will require drug tablet return 7 days after the extraction. The antibiotic and placebo tablets will have the same size and color. In this way, all patients (Group 1, 2 or 3) will start taking medication (placebo or antibiotic according to the group) two days before the tooth extraction and continue 5 days after
Sponsors
María del Mar Mariscal Cazalla
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Caregiver)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Volunteer patients of the Master of Oral Surgery and Implantology demanding an extraction of a third lower molar
Exclusion criteria
- Pregnant or breastfeeding period. -Patients with some systemic pathology. Only patients ASA I (classification of the American Society of Anesthesiology) will be included in the study. - Previous medical allergies to any drugs used in this study - Patients have taken antibiotics one week before the surgery
Outcome results
None listed