Comparing post-sinus surgery symptoms of chronic sinusitis patients using Flo Sinus Care or Flo Kappa sinus rinses

Comparing the immediate post-operative outcomes of patients after sinus surgery when they rinse with Flo Kappa sinus rinse kit, compared to the standard of care rinse kit (Flo Sinus Care). The study will have two randomised double-blinded arms: Control (standard of care rinse Flo Sinus Care), n=25 Flo Kappa rinse, n=25 After sinus surgery, patients will be randomly allocated standard of care sinus rinse kit (Flo Sinus Care) or modified rinse kit containing seaweed extract, kappa carrageenan (Flo Kappa). The kits consist of a clear plastic rinse bottle with nozzle and 1.9g powder sachets for reconstitution in 200mL boiled tepid water. Once reconstituted, the solution consists of sodium chloride (0.772%w/v), potassium chloride (0.042%w/v), calcium lactate pentahydrate (0.032%w/v), sodium bicarbonate (0.015%w/v), glucose anhydrous (0.085%w/v), and kappa carrageenan (0.12%w/v). This closely resembles Lactated Ringer's solution (plus kappa carrageenan). Isotonic pH of 7.2-8.0. No other chemicals or preservatives. The participant will mix one sachet per one 200mL rinse bottle, and douche with one bottle (and one sachet) per side of the nose. Hence be using two bottles (and two sachets) per nasal rinse. This is repeated 4 times per day (i.e. 8 rinse bottle and 8 sachets per day) for the first 2 weeks, then 2 times per day (4 rinse bottles and 4 sachets per day) for another 10 weeks. The washing schedule will run for 12 weeks total. The kit and sachets will be provided to the participant upon discharge from the hospital, with instructions for use. Neither the PI, follow-up doctors, or trial coordinators will know which sachets the participant is given, the treatments will be blinded by Pharmacy. The participant is given verbal and written instruction on the intervention mode and frequency upon consent to the trial. Their adherence to the rinsing schedule will be checked at post-op visit 2 weeks, 6-8 weeks and 3 months (exit visit) by a Trial Coordinator. A Trial Coordinator will accompany the patient to these post-op visits, when they see their ENT doctor. During these standard of care appointments, questionnaire, a nasal swab and a mucus sample is collected along with sinus endoscopic score. Adverse side events and concomitant medications are also checked at each appointment.