The impact of vitamin d level on in vitro fertilisation outcomes

The association of vitamin d status with clinical pregnancy and live birth outcomes in women undergoing in vitro fertilisation

Status

Completed

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12619000083190

Acronym

Nil

Enrollment

429

Registered

2019-01-21

Start date

2018-12-24

Completion date

2019-01-13

Last updated

2019-01-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

To determine the association between patient serum vitamin d status and clinical IVF outcomes such as clinical pregnancy and live births arising from fresh embryos transferred. Our hypothesis is that those with a sufficient vitamin d status (> 50 nmol/L) will have more favourable outcomes in comparison to those with insufficient levels (< 50 nmol/L). We will examine vitamin d status as a continuous and as categorical variables while adjusting for various other infertility parameters including patient age and ovarian reserve.

Interventions

All fresh embryo transfer treatment cycles initiated from 1st April 2008 to 30th June 2016 will be retrospectively extracted from PIVET Medical Centre’s long-established, validated database. The data including patients vitamin d level was recorded as part of routine clinical practice at PIVET. Approval for analysis and publication of such retrospective data was initially provided by Curtin University Human Research Ethics Committee in 2010, annually renewed since then with the latest annual appr

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

All eligible patients attending our IVF clinic consenting to the research and with a fresh embryo transfer. Vitamin d tested with 90 days of embryo transfer. Only the first chronological cycle for patients within the study time frame.

Exclusion criteria

Patients with no fresh embryo transfer cycles such as cancelled cycles, failed fertilisations, failed egg retrieval and freeze all cycles were excluded. Donor recipients (inclusive of semen, oocytes and embryos) were also excluded to minimise participant complexity in terms of the donor vs. recipient VitD status. Patients with a history of thyroid, renal, liver or metabolic disease. Patients with a vitamin d measurement more than 90 days before or after embryo transfer.

Outcome results