None listed
Conditions
Brief summary
The aim of this study is to define what is a normal blood glucose level post meal in people without diabetes. This study involves consuming five standardised test meals of varying macronutrient composition over five days. To assess the effect of each meal on post-meal blood glucose participant glucose levels will be measured continuously for 4 hours post- meal.
Interventions
This study involves the provision of five standardised test meals of varying macronutrient composition, 4 breakfast meals (see below) and 1 dinner meal (pizza, Carbohydrate:76g, Fat:45g, Protein:55g) to be consumed over five days (inclusive of a 24 hour washout period between intervention). Test meals must be consumed in their entirety within 20 minutes. Test meals will be randomised to days using a block design. To assess the effect of each meal on postprandial glycaemia participant interstiti
This study involves the provision of five standardised test meals of varying macronutrient composition, 4 breakfast meals (see below) and 1 dinner meal (pizza, Carbohydrate:76g, Fat:45g, Protein:55g) to be consumed over five days (inclusive of a 24 hour washout period between intervention). Test meals must be consumed in their entirety within 20 minutes. Test meals will be randomised to days using a block design. To assess the effect of each meal on postprandial glycaemia participant interstitial glucose levels will be measured continuously for 4 hours post- meal consumption using a continuous glucose monitor. breakfast meals 1. Carbohydrate:30g, Fat: less than 10g, Protein: less than 10g (toast with butter) 2.Carbohydrate:30g, Fat:40g, Protein: less than 10g (cheesecake muffin) 3.Carbohydrate:30g, Fat: less than 10g, Protein: 50g (protein milkshake) 4. Carbohydrate:30g, Fat:40g, Protein: 50g (protein milkshake with muesli bar)
Sponsors
John Hunter Charitable Trust
Study design
Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
10 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
• HbA1c less than or equal to 5.6% (37.7 mmol/mol) (capillary) • Fasting blood glucose less than or equal to 5.5 mmol/L (capillary) • Non- obese [BMI less than 95th percentile (less than or equal to 20 years) or BMI less than 30 kg/m2 (greater than 20 years)]
Exclusion criteria
• Pre- diabetic or diabetic (as defined in the American Diabetes Association Standards of Medical Care in Diabetes, 2018) • Allergies or intolerances that would prevent test meal consumption e.g Coeliac Disease • Medications that may alter glycaemia • Any other major medical condition
Outcome results
None listed