Profile of pathogens causing acute cholangitis as a guide to antibiotics selection: A review of 395 acute cholangitis admissions in an Australian tertiary centre.

Status

Completed

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12619000053123

Enrollment

395

Registered

2019-01-15

Start date

2017-03-08

Completion date

2017-07-31

Last updated

2019-01-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Australian data on pathogens causing acute cholangitis is lacking. Americian, European and Asian data state that E.Coli, Klebsiella species and Enterococcus species are the three most common pathogens causing acute cholangitis. This study aims to identify pathogens causing acute cholangitis from positive blood cultures in an Australian setting as a guide to antibiotics selection and to analyse their impact on in-hospital length of stay (LOS).

Interventions

Retrospective analysis of all admissions with acute cholangitis between January 2010 and December 2016. Each admission was categorised according to underlying aetiology, presence of biliary stent, choledocholithiasis, previous endoscopic biliary manipulation, immunosuppression, liver transplantation and representation. Each category was compared in relation to the pathogens grown, in-hospital length of stay (LOS) and Intensive Care Unit length of stay (ICU-LOS).

Eligibility

Sex/Gender

All

Age

49 Years to 81 Years

Healthy volunteers

Inclusion criteria

Included only admissions with "definite" daignoses of acute cholangitis as per Tokyo Guidelines

Exclusion criteria

No exclusion criteria

Outcome results