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Benefits of high intensity interval training in people with fibrotic interstitial lung disease

Effect of high intensity interval training on exercise endurance in fibrotic interstitial lung disease

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12619000019101
Acronym
HIIT in fILD
Enrollment
131
Registered
2019-01-09
Start date
2019-07-17
Completion date
2024-01-15
Last updated
2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The fibrotic interstitial lung diseases (fILD) is a group of debilitating chronic lung conditions that are characterised by scarring of lung tissue, dyspnoea on exertion and significant physical impairment. Exercise training is recommended for people with fILD in improving breathlessness and exercise tolerance. However, despite the best efforts of patients and clinicians, many of those who participate are not attaining its benefits. The current exercise training strategies of moderate intensity continuous training may not be well suited to fILD. High intensity interval training, short bouts of high-intensity exercise regularly interspersed with periods of rest or light exercise may be an alternate exercise training option for people with fILD. People with fILD will be recruited and randomly allocated to receive either the traditional PR model of moderate intensity continuous training or high intensity interval training. The aim of this study is to determine to whether high intensity interval training is better than the current method of continuous exercise training at moderate intensity in improving exercise tolerance, breathlessness and quality of life in people with fILD.

Interventions

High Intensity Interval training Participants in will undergo a twice-weekly supervised exercise training program for 8 weeks. The exercise training will occur during the standard pulmonary rehabilitation program of each hospital (Alfred, Austin, Royal Prince Alfred or Prince Charles Hospital). Each session, participants will undertake 36 minutes of stationary cycling; alternating 30 seconds exercise intervals at 100% of peak work rate, achieved on the cardiopulmonary exercise test (CPET), wi

High Intensity Interval training Participants in will undergo a twice-weekly supervised exercise training program for 8 weeks. The exercise training will occur during the standard pulmonary rehabilitation program of each hospital (Alfred, Austin, Royal Prince Alfred or Prince Charles Hospital). Each session, participants will undertake 36 minutes of stationary cycling; alternating 30 seconds exercise intervals at 100% of peak work rate, achieved on the cardiopulmonary exercise test (CPET), with 30-seconds of unloaded pedalling. Participants will also undertake the same resistance program as traditional PR. Exercise training and weekly progressions will be standardised across all sites. Supplemental oxygen will be provided during training if the participant is on long term oxygen therapy or if SpO2 on room air is <85% whilst exercising and accompanied by symptoms and signs of severe hypoxemia. All participants will be encouraged to perform an additional three unsupervised sessions each week of aerobic exercise at an intensity and duration similar to that achieved in the supervised sessions.

Sponsors

La Trobe University
Lead SponsorUniversity

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Outcomes Assessor)

Eligibility

Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

Fibrotic interstitial lung disease

Exclusion criteria

Resting SpO2 is < 85% Severe pulmonary hypertension (WHO class IV) Attendance at Pulmonary rehabilitation (PR) within last 12 months Comorbidities which preclude exercise training History of syncope on exertion Significant cognitive impairment Anticipated transplant or death within the duration of the study period

Outcome results

None listed

Source: ANZCTR · Data processed: Apr 4, 2026