None listed
Conditions
Brief summary
The purpose of this study is to determine the role of blood molecules and imaging in the detection of early heart damage in women undergoing radiation treatment. Who is it for? You may be eligible for this study if you are over the age of 18 years, have left sided breast cancer and are undergoing radiation therapy at the Olivia Newton John Cancer and Wellness Centre in Melbourne. Study details All participants in this study will have a blood test on day 1 to 5 of the first week of radiation treatment and then on day 1 of each subsequent week. This will be to measure the levels of blood molecules related to heart damage. Participants will also have a heart ultrasound (echocardiogram) before they start treatment and when they finish treatment. The intention of this study is to identify early damage to the heart muscle during radiation therapy. If we can identify those patients with early damage we can follow them into the future to ensure they do not develop symptomatic heart disease.
Interventions
Patients will have an ECG performed prior to commencing radiation therapy and at the end of their treatment course. Patients will undergo blood sampling at Day 1 to Day 5 of the first week of radiation therapy which will be performed on arrival for their treatment. Following the first week blood will be sampled only on Day 1 of the subsequent weeks for the duration of the treatment schedule. Patients will also undergo cardiac ultrasound with transthoracic echocardiography with a machine capable
Patients will have an ECG performed prior to commencing radiation therapy and at the end of their treatment course. Patients will undergo blood sampling at Day 1 to Day 5 of the first week of radiation therapy which will be performed on arrival for their treatment. Following the first week blood will be sampled only on Day 1 of the subsequent weeks for the duration of the treatment schedule. Patients will also undergo cardiac ultrasound with transthoracic echocardiography with a machine capable of calculating strain rates on the images obtained. This will be performed prior to commencing radiation therapy, immediately after finishing the 6-week course of radiation therapy and at least 12-months after treatment and will be assessed by a cardiologist for reduction in left ventricular function.
Sponsors
Austin Health Medical Research Foundation
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
All women over the age of 18 years with left sided breast cancer undergoing radiation therapy at the Olivia Newton John Cancer and Wellness Centre
Exclusion criteria
Patients who are receiving adjuvant chemotherapy or Herceptin. Patients who are unable to provide informed consent will be excluded. Additionally, patients who withdraw their consent at any stage will be excluded from the rest of the study.
Outcome results
None listed