None listed
Conditions
Brief summary
Background: This NHMRC funded project (2018-2021) will determine how music listening impacts on language-related brain activity, brain structure and connectivity in post-stroke aphasia. Aims and Method: The specific aims of this resaerch are to (1) Determine whether daily music listening in addition to usual care will result in superior aphasia recovery compared to usual care only, as measured by standard clinical language and communication assessments. (2) Identify the effect of music listening on cognition and mood and the relationship between these factors and aphasia recovery. (3) Determine the effect of music listening on language-related brain activity, brain structure and brain connectivity using advanced imaging techniques developed for this population. (4) Determine if brain activity and structure predicts aphasia recovery in response to music listening and examine the influence of genetic factors and stress levels in recovery and response to music. 94 Participants with post-stroke aphasia will be scanned and undertake tests of language, cognition, mood, and music processing 2-4 weeks post-onset. They will then receive either usual care only or will listen to music daily (minimum 1 hour) in addition to receiving usual care until three months post-stroke. All participants will be scanned and re-tested at three months and six months post-onset. Outcomes: This approach will provide important insights into the mechanisms driving music-induced recovery of language and will identify potential responders to this treatment.
Interventions
The patient cohort will be randomly assigned to either treatment (music listening) + usual care, or a usual care only control condition (stratified based on severity of language deficit).
Treatment Group:
• The participants assigned to the music listening intervention will be provided with an iPad mini and an Apple Music subscription with their own personalised playlist for the duration of their music listening treatment. An allied health professional (i.e., music therapist, speech pathologist,
The patient cohort will be randomly assigned to either treatment (music listening) + usual care, or a usual care only control condition (stratified based on severity of language deficit). Treatment Group: • The participants assigned to the music listening intervention will be provided with an iPad mini and an Apple Music subscription with their own personalised playlist for the duration of their music listening treatment. An allied health professional (i.e., music therapist, speech pathologist, or allied health assistant), will guide playlist selection and instruct participants on how to access, and listen, to music on the device. • Participants will be instructed to listen to at least 1 hour of music per day (with feedback of total daily listening time provided via the Play Time app). Specific details such as time of day listening occurred, duration of listening for each session, each date listening has taken place, and which songs were listened to are recorded within the Play Time app (with a weekly breakdown of listening activity available). • All participants will also receive usual aphasia treatment delivered by their treating speech pathologists available in each specific health service in which the patient is recruited.
Sponsors
Professor David Copland
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
18 Years to 85 No limit
Healthy volunteers
Yes
Inclusion criteria
People with Aphasia 1) Single left hemisphere stroke (as diagnosed by neurologist or physician and confirmed by MRI or CT) and speech or language impairment as identified by a speech pathologist or other relevant medical, nursing or allied health staff; 2) below the aphasia cut-off (93.8 AQ) on the Western Aphasia Battery-Revised (WAB-R); 3) medical stability; 4) able to complete a behavioural language, cognitive, mood, and music processing battery between 2-4 weeks post-stroke; 5) have sufficient vision and hearing to complete the imaging and behavioural tasks; and 6) proficient in English language prior to stroke. Healthy Controls: 1. English as first language 2. Right Handed 3. Sufficient hearing and vision to complete the imaging and behavioural tasks
Exclusion criteria
People with Aphasia: 1) Any other neurological disease or disorder, mental illness, dementia, head trauma, alcoholism, cerebral tumour or abscess; 2) Participants will be excluded from scanning if they have any metals present in the body or other contraindications for MRI including claustrophobia, or if severe auditory comprehension deficits preclude them from following directions in the MRI scanner; 3) uncorrected vision or hearing impairment (confirmed with pure tone audiometry); 4) unable to access music playing device due to significant motor or cognitive deficits; and 5) major clinical depression or other mental health condition that may affect participation. Healthy Controls; 1. Any brain/neurological disorder, mental illness, head trauma, alcoholism and cerebral tumor 2. Any contraindications for MRI - claustrophobia or metals present in the body e.g. pacemaker, heart valve, dental bridge, metal mesh implants/clips/wire sutures, hearing implant etc.
Outcome results
None listed