None listed
Conditions
Brief summary
The study will follow a cohort of high risk pregnant women and assess for and treat OSA with CPAP therapy. Maternal blood pressure will be monitored throughout pregnancy and is the primary outcome between the two groups of participants (those with OSA compared with those without OSA). Quality of life will be assessed during pregnancy to determine if treating OSA improves quality of life. Placental vascular health will be monitored via ultrasound assessment at 28, 32 and 36 weeks gestational age followed by pathological examination of the placenta following delivery. Those women with a diagnosis of OSA during pregnancy will be reassessed for persistence of OSA at 6 months post partum.
Interventions
Autotitrating continuous airway pressure (CPAP) will be prescribed from a pressure of 4-20 cm H2O, for a minimum of 4 hours per night, to all pregnant women diagnosed with obstructive sleep apnea (as defined by an apnea-hypopnea index (AHI) of >10/hr) following a diagnostic polysomnogram and consultation with a sleep physician. Compliance to treatment will be individualized and assessed on a weekly basis by the sleep physician with the assistance of the sleep nurse and CPAP provider. Treatment
Autotitrating continuous airway pressure (CPAP) will be prescribed from a pressure of 4-20 cm H2O, for a minimum of 4 hours per night, to all pregnant women diagnosed with obstructive sleep apnea (as defined by an apnea-hypopnea index (AHI) of >10/hr) following a diagnostic polysomnogram and consultation with a sleep physician. Compliance to treatment will be individualized and assessed on a weekly basis by the sleep physician with the assistance of the sleep nurse and CPAP provider. Treatment with CPAP therapy will continue from the time of diagnosis of OSA up until 6 months post-partum following a repeat diagnostic sleep study.
Sponsors
Flinders Medical Centre
Study design
Allocation
Non-randomised trial
Intervention model
Other
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Healthy volunteers
No
Inclusion criteria
Early pregnancy BMI of 35 kg/m2 or more Gestational age less than 28 weeks Ability to given informed consent
Exclusion criteria
Lack of regular attendance at clinic appointments Illicit or intravenous drug use Current cigarette smoking Known diagnosis of OSA already established on CPAP therapy Type 1 diabetes mellitus Pulmonary hypertension cardiomyopathy
Outcome results
None listed