Efficacy and safety of Artemether-Lumefantrine (A-L) for P.falciparum malaria and Pyronaridine-Artesunate (P-A) for treatment of uncomplicated Plasmodium falciparum malaria and P. vivax malaria in Myit Kyi Nar township, Kachin state and Kyauk Mee township, Northern Shan state

Non- randomized controlled trial for falciparum malaria, where one arm was given A-L and the second arm was given P-A . All falciparum patients who met the inclusion criteria were enrolled. Odd numbers were given A-L which was given as oral tablets twice a day for three according to the dosing chart. A-L ( each tablet contains 20 mg artemether & 120 mg lumefantrine) was given according to the body weight as: (a) 15-24 Kg.body weight: two tablets twice a day for three days (b) 25-34 Kg.body weight: three tablets twice a day for three days (c) 35 and above: four tablets twice a day for three days Even numbers were administered oral P-A tablet ( each tablet contains Pyronaridine 60 mg & artesunate 20 mg) was given according to the body weight as: (a) 20-24 Kg.body weight: one tablet three times a day for three days (b) 25-44 Kg.body weight: two tablets three a day for three days (c) 45 - 65 Kg. body weight : three tablets three times a day for three days Adherence of treatment was monitored by asking to show the the empty drug card in the follow up visits. Patients having P.vivax as detected ny microscopic examination were treated with P-A while the dosage was the same for P. falciparum malaria.