A study of lung function using MRI scans in people with moderate chronic lung disease

A comparative study: measuring ventilation (V) and perfusion (Q) in healthy volunteers and patients with moderate chronic respiratory disease

Status

Not yet recruiting

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12618001942246

Enrollment

Registered

2018-11-29

Start date

2018-12-03

Completion date

2019-03-29

Last updated

2018-12-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The aim of the study is to develop functional MRI capabilities at the Centre for Advanced MRI (CAMRI) to measure regional lung function. This is a proof of concept study - to develop, test and establish functional MRI techniques – providing a non-invasive, non-ionising imaging method to measure regional ventilation, perfusion and tissue density in the lung. Initial protocol development has been undertaken in approximately 8 healthy volunteers. This will now be followed by a comparative study of measurements of ventilation (V) and perfusion (Q) in approximately 8 patients with various respiratory disease (with known V/Q dysfunction) against data from 8 healthy age matched volunteers.

Interventions

magnetic resonance imaging (MRI) The test will be administered a trained medical physicist and radiology technologist at the Centre for Cardiac Magnetic Resonance Imaging at the University of Auckland. Each participant will have one MRI and the torso will be imaged. There is no radiation dose. The procedure takes approximately 30 minutes. Eight healthy volunteers have already been recruited and the data from those participants helped set the algorithms for the study of 8 participants with diseas

Study design

Allocation

Non-randomised trial

Primary purpose

Diagnosis

Eligibility

Sex/Gender

All

Age

40 Years to No maximum

Healthy volunteers

Inclusion criteria

Adult patients with moderate severity COPD or idiopathic pulmonary fibrosis COPD: FEV1 <70% >50% predicted IPF: FVC < 90 >50% predicted and/or DLCO <80 >50% predicted

Exclusion criteria

inability to lie flat for MRI scan

Outcome results