Do frozen embryos generated under the influence of growth hormone implant at a higher rate?

Implantation potential and pregnancy outcomes of vitrified-autologous embryos generated under growth hormone stimulation

Status

Completed

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12618001933246

Enrollment

1119

Registered

2018-11-28

Start date

2018-02-01

Completion date

2018-03-31

Last updated

2018-12-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

To determine the clinical pregnancy and live births arising from frozen embryos transferred (FET) which had been generated under the influence of IVF adjuvants given to women categorised as poor prognosis. Our hypothesis is that growth hormone, but not other adjuvants, administered in stimulation cycles may improve oocytes with resultant benefits to embryo quality which in turn may result in improved Clinical Pregnancy and Live Birth rates in subsequent FET cycles.

Interventions

All frozen embryo transfer treatment cycles initiated from 1st April 2008 to 31st March 2017 were retrospectively extracted from PIVET Medical Centre’s long-established, validated database where growth hormone or other adjuvants were used. The data was recorded as part of routine clinical practice at PIVET. Approval for analysis and publication of such retrospective data was initially provided by Curtin University Human Research Ethics Committee in 2010, annually renewed since then with the late

Eligibility

Sex/Gender

All

Age

20 Years to 48 Years

Healthy volunteers

Inclusion criteria

Of 2518 frozen embryo transfer cycles conducted during the time frame, included all 1119 vitrified embryos undergoing first treatment cycle with single embryo transfer applying an HRT shedule.

Exclusion criteria

Natural cycles and stimulated cycles. double embryo transfers and repeat FET cycles.

Outcome results