None listed
Conditions
Brief summary
A complete obstetrical history, clinical examination and laboratory investigations will be done to the studied women to exclude the conditions affecting urinary protein/creatinine ratio (as chronic renal disease). The studied women will be admitted for moderate 24 hours bed rest, control of blood pressure and for the 24-hour urine collection for assessment of proteinuria, which started on the morning following the hospitalization. Spot mid-stream urine specimens (first morning urine sample) for measuring protein/creatinine ratio will be obtained shortly before the 24-hour urine collection. Collected data at the end of the study will statistically analyzed to evaluate the accuracy of protein to creatinine ratio versus 24-hour urine collection in detection of remarkable proteinuria in preeclampsia.
Interventions
Preeclampsia defined as the presence of hypertension and urinary proteins after 20 weeks` gestation. Hypertension defined as blood pressure more than or equal 140/90 mmHg. Urinary protein defined as the presence of more than or equal 300 mg protein in the 24-hour collected urine and/or a positive urine dipstick test.
The studied women will be admitted for moderate 24 hours bed rest, control of blood pressure and for the 24-hour urine collection for assessment of proteinuria, which started on t
Preeclampsia defined as the presence of hypertension and urinary proteins after 20 weeks` gestation. Hypertension defined as blood pressure more than or equal 140/90 mmHg. Urinary protein defined as the presence of more than or equal 300 mg protein in the 24-hour collected urine and/or a positive urine dipstick test. The studied women will be admitted for moderate 24 hours bed rest, control of blood pressure and for the 24-hour urine collection for assessment of proteinuria, which started on the morning following the hospitalization. Spot mid-stream urine specimens (first morning urine sample) for measuring protein/creatinine ratio will be obtained shortly before the 24-hour urine collection. Urinary protein will be determined by the Biuret method. Urine creatinine level will be measured by a modified Jaffe test.
Sponsors
Ibrahim A. Abdelazim
Eligibility
Sex/Gender
All
Age
20 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
Women between 20-40 years old, diagnosed as preeclampsia and admitted for control of blood pressure and investigations after 20 weeks` gestation during the period from December 2018 till December 2019 after informed consent and approval of the study by the local ethical committee of both hospitals.
Exclusion criteria
Women > 40 years, women with chronic hypertension, gestational hypertension (without proteinuria), diabetes, pre-existing chronic renal disease or urinary tract infections, refused to participate and/or refused to give consent.
Outcome results
None listed